40611-30-1

Basic information

• Product Name: Benzoic acid, 4-[[(benzoylamino)thioxomethyl]amino]-
• CAS NO: 40611-30-1
• Molecular Formula: C15H12N2O3S
• Molecular Weight: 300.338
• Mol File: 40611-30-1.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: Benzoic acid, 4-[[(benzoylamino)thioxomethyl]amino]-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 4-[[(benzoylamino)thioxomethyl]amino]-(40611-30-1)
• EPA Substance Registry System: Benzoic acid, 4-[[(benzoylamino)thioxomethyl]amino]-(40611-30-1)

Safety Data

• Hazardous Substances Data: 40611-30-1(Hazardous Substances Data)

Upstream product

• 150-13-0 4-amino-benzoic acid 
• 532-55-8 Benzoyl isothiocyanate 
• 1147550-11-5 ammonium thiocyanate 
• 98-88-4 benzoyl chloride 

Downstream Products

• 1262955-08-7 N-benzoyl-N'-(4-benzoxy)thiourea sodium salt 
• 4596-39-8 4-(2-chloroacetamido)benzoic acid 
• 1392572-92-7 4-(2-imino-4-oxothiazolidin-3-yl)benzoic acid 
• 37182-78-8 4-(4-phenylthiazol-2-ylamino) benzoic acid 
• 7366-56-5 4-thioureidobenzoic acid 

Relevant articles and documents

Spectroscopic studies and structure of 4-(3-benzoylthioureido)benzoic acid

4-(3-Benzoylthioureido)benzoic acid has been synthesized from the reaction of 4-aminobenzoic acid with benzoyl isothiocyanate. The title compound has been characterized by elemental analysis, MS, FT-IR, 1H-NMR, 13C-NMR and UV-Visible

Synthesis, characterization, antimicrobial and cytotoxic activity of novel half-sandwich Ru(II) arene complexes with benzoylthiourea derivatives

Three new ruthenium(II)-arene complexes, [Ru(η6-p-cymene)(L1)Cl2] (C1) where L1 is N-((4 methoxyphenyl)carbamothioyl)benzamide; [Ru(η6-p-cymene)(L2)Cl2] (C2) where L2

Facile synthesis of some condensed 1,3-thiazines and thiazoles under conventional conditions: antitumor activity

1,3-Thiazine 3 was obtained from cinnamoyl thiourea derivative 2 as the kinetic control product. Refluxing of 2 with sodium ethoxide afforded pyrimidine derivative 4. Moreover, stirring of 2 with bromine/acetic acid gave thiazole 5 that was condensed with o-phenylene diamine forming benzimidazole 6. Heating of arylthiourea 8 with maleic anhydride or phenacyl chloride afforded thiazole derivatives 9 and 10, respectively. Condensation of compound 10 with o-phenylene diamine gave benzimidazole 11. Reaction of p-amino benzoic acid with chloro acetyl isothiocyanate, acetylacetone and ethylacetoacetate produced imidazole 14, enaminone 15 and crotonate 16 derivatives, respectively. Stirring a mixture of benzoyl isothiocyanate with 15 and/or 16 resulted in pyridine-2-thione 17. The yields of the prepared compounds were 41–93%. The experimental section is simple and easy. The detailed synthesis, spectroscopic data, IC50 and antitumor activity of the synthesized compounds were reported. The cytotoxicity of the newly synthesized products showed that compound 4 is the most active compound towards the cancer cell line at which its reactivity is higher than that of the standard doxorubicin (anticancer reference drug).