40615-17-6 Usage
Description
3-AMINO-3,4-DIHYDROQUINOLIN-2(1H)-ONE is an organic compound that serves as a crucial intermediate in the synthesis of various pharmaceutical compounds. Its chemical structure allows it to be a versatile building block in the development of new drugs, particularly those targeting specific enzymes or biological processes.
Uses
Used in Pharmaceutical Industry:
3-AMINO-3,4-DIHYDROQUINOLIN-2(1H)-ONE is used as an intermediate for the preparation of thienopyrroles, which are known as glycogen phosphorylase inhibitors. These inhibitors play a significant role in the development of treatments for various metabolic disorders and conditions related to energy metabolism.
Additionally, 3-AMINO-3,4-DIHYDROQUINOLIN-2(1H)-ONE is identified as an impurity in Melphalan (M216900), a chemotherapy drug used to treat certain types of cancer. The presence of this compound in the drug may have implications for its efficacy, safety, and overall pharmaceutical quality. As a result, its identification and control are essential in the manufacturing process of Melphalan to ensure the drug's effectiveness and minimize potential side effects.
Check Digit Verification of cas no
The CAS Registry Mumber 40615-17-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 4,0,6,1 and 5 respectively; the second part has 2 digits, 1 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 40615-17:
(7*4)+(6*0)+(5*6)+(4*1)+(3*5)+(2*1)+(1*7)=86
86 % 10 = 6
So 40615-17-6 is a valid CAS Registry Number.
InChI:InChI=1/C9H10N2O.ClH/c10-7-5-6-3-1-2-4-8(6)11-9(7)12;/h1-4,7H,5,10H2,(H,11,12);1H
40615-17-6Relevant articles and documents
(4 + 2) cyclization of aza-o-quinone methides with azlactones: construction of biologically important dihydroquinolinone frameworks
Wang, Hai-Qing,Ma, Wenjing,Sun, Ao,Sun, Xin-Yue,Jiang, Chao,Zhang, Yu-Chen,Shi, Feng
, p. 1334 - 1343 (2021)
A base-promoted (4 + 2) cyclization of aza-o-quinone methides (aza-o-QMs)in situgenerated fromN-(o-chloromethyl)aryl amides was established. In this approach, azlactones were utilized as competent two-atom reaction partners to undergo (4 + 2) cyclization with aza-o-QMs, which afforded a series of dihydroquinolinone derivatives in overall good yields (up to 98%). This protocol has not only advanced the development of aza-o-QM-involved reactions, but also offered a useful method for constructing biologically important dihydroquinolinone frameworks.
INDOLE AHR INHIBITORS AND USES THEREOF
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Paragraph 00307, (2020/05/21)
The present invention provides compounds useful as inhibitors of AHR, compositions thereof, and methods of using the same.
The enantioselective synthesis of (R)- and (S)-3-amino-3,4-dihydro-1H-[1,8] naphthyridin-2-one
Londregan, Allyn T.,Bernhardson, David,Bradow, James,Makowski, Teresa M.,Storer, Gregory,Warmus, Joseph,Wooten, Ceshea,Yang, Xiaojing
scheme or table, p. 2072 - 2075 (2010/10/04)
A number of approaches to the enantioselective synthesis of (R)- and (S)-3-amino-3,4-dihydro-1H-[1,8]naphthyridin-2-one were studied. A novel one-pot asymmetric reduction/lactamization provided the desired products in high yield and enantiomeric excess.
