4066-41-5 Usage
Description
5-Acetylthiophene-2-carboxylic acid is an organic compound that serves as a key intermediate in the synthesis of various 2,5-disubstituted thiophenes. It is characterized by its unique chemical structure, which includes a thiophene ring with an acetyl group at the 5-position and a carboxylic acid group at the 2-position. 5-Acetylthiophene-2-carboxylic acid is known for its potential applications in the chemical and pharmaceutical industries due to its versatile reactivity and functional groups.
Uses
Used in Chemical Synthesis:
5-Acetylthiophene-2-carboxylic acid is used as a synthetic intermediate for the preparation of 2,5-disubstituted thiophenes. These substituted thiophenes are important building blocks in the development of various organic compounds, including pharmaceuticals, agrochemicals, and advanced materials.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 5-Acetylthiophene-2-carboxylic acid is used as a starting material for the synthesis of therapeutically relevant compounds. 5-Acetylthiophene-2-carboxylic acid's functional groups can be further modified to create novel drug candidates with potential applications in the treatment of various diseases and medical conditions.
Used in Material Science:
5-Acetylthiophene-2-carboxylic acid is also utilized in the field of material science, particularly in the development of organic electronic materials such as organic semiconductors and conductive polymers. 5-Acetylthiophene-2-carboxylic acid's unique electronic properties make it a valuable component in the design and synthesis of advanced materials with potential applications in electronic devices, sensors, and energy storage systems.
Used in Dye and Pigment Industry:
5-Acetylthiophene-2-carboxylic acid's ability to form various 2,5-disubstituted thiophenes also makes it a valuable intermediate in the dye and pigment industry. These substituted thiophenes can be used to create a wide range of colors and shades, offering new possibilities for the development of novel dyes and pigments with improved properties, such as enhanced color strength, stability, and environmental friendliness.
Synthesis Reference(s)
Journal of Heterocyclic Chemistry, 3, p. 104, 1966 DOI: 10.1002/jhet.5570030127
Check Digit Verification of cas no
The CAS Registry Mumber 4066-41-5 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,0,6 and 6 respectively; the second part has 2 digits, 4 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 4066-41:
(6*4)+(5*0)+(4*6)+(3*6)+(2*4)+(1*1)=75
75 % 10 = 5
So 4066-41-5 is a valid CAS Registry Number.
InChI:InChI=1/C7H6O3S/c1-4(8)5-2-3-6(11-5)7(9)10/h2-3H,1H3,(H,9,10)
4066-41-5Relevant articles and documents
Photo-induced deep aerobic oxidation of alkyl aromatics
Wang, Chang-Cheng,Zhang, Guo-Xiang,Zuo, Zhi-Wei,Zeng, Rong,Zhai, Dan-Dan,Liu, Feng,Shi, Zhang-Jie
, p. 1487 - 1492 (2021/07/10)
Oxidation is a major chemical process to produce oxygenated chemicals in both nature and the chemical industry. Presently, the industrial manufacture of benzoic acids and benzene polycarboxylic acids (BPCAs) is mainly based on the deep oxidation of polyalkyl benzene, which is somewhat suffering from environmental and economical disadvantage due to the formation of ozone-depleting MeBr and corrosion hazards of production equipment. In this report, photo-induced deep aerobic oxidation of (poly)alkyl benzene to benzene (poly)carboxylic acids was developed. CeCl3 was proved to be an efficient HAT (hydrogen atom transfer) catalyst in the presence of alcohol as both hydrogen and electron shuttle. Dioxygen (O2) was found as a sole terminal oxidant. In most cases, pure products were easily isolated by simple filtration, implying large-scale implementation advantages. The reaction provides an ideal protocol to produce valuable fine chemicals from naturally abundant petroleum feedstocks. [Figure not available: see fulltext.].
A 2 - carboxamide - 5 - (2 - mercapto - 1, 3 - thiazole - 4 - yl) - thiophene preparation method
-
Paragraph 0028; 0029, (2017/08/25)
The invention discloses a preparation method of 2-formylamine-5-(2-sulfhydryl-1, 3-thiazole-4-base)-thiophene. The preparation method comprises the following steps: firstly synthetizing 2-(alpha-methoxyl group ammonia) ethylthiophene, then successively synthetizing 5-acetyl -2-(alpha-methoxyl group ammonia) ethylthiophene, 5-(alpha-methoxyl group ammonia) ethyl-2-thiophene carboxylic acid and a crude product of a 5-acetyl-2-thiophene carboxylic acid, after the crude product of the 5-acetyl-2-thiophene carboxylic acid is re-refined, then successively synthetizing 5-acetyl-2- thiophene acyl chloride, 5-acetyl-2-thiophene acidamide, 5-bromo acetyl -2-thiophene acidamide and 5-acidamide-2-thiophene acetyl thiocyanates, and finally synthetizing the product of the 2-formylamine-5-(2-sulfhydryl-1, 3-thiazole-4-base)-thiophene. The 2-formylamine-5-(2-sulfhydryl-1, 3-thiazole-4-base)-thiophene prepared by the preparation method disclosed by the invention is good in quality and high in yield.
Friedel-Crafts acylation with malonic acids in polyphosphoric acid
Renault, Olivier,Dallemagne, Patrick,Rault, Sylvain
, p. 324 - 328 (2007/10/03)
-