40759-47-5

Basic information

• Product Name: 1-(2-methanesulfonyloxyethyl)-4-fluorobenzene
• Synonyms: 1-(2-methanesulfonyloxyethyl)-4-fluorobenzene
• CAS NO: 40759-47-5
• Molecular Weight: 218.249
• Mol File: 40759-47-5.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 1-(2-methanesulfonyloxyethyl)-4-fluorobenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-methanesulfonyloxyethyl)-4-fluorobenzene(40759-47-5)
• EPA Substance Registry System: 1-(2-methanesulfonyloxyethyl)-4-fluorobenzene(40759-47-5)

Safety Data

• Hazardous Substances Data: 40759-47-5(Hazardous Substances Data)

Upstream product

• 7589-27-7 2-(4-Fluorophenyl)ethanol 
• 124-63-0 methanesulfonyl chloride 

Downstream Products

• 1189800-66-5 C₂₂H₂₄ClFN₂ 
• 1189800-18-7 C₂₁H₂₂ClFN₂ 
• 1176280-87-7 (S)-7-(4-fluorobenzyloxy)-10-(4-fluorophenethyl)-10,11a-dihydro-1H-benzo[e]pyrrolo[1,2-a][1,4]diazepin-3,11(2H,5H)-dione 

Relevant articles and documents

HISTONE DEMETHYLASE INHIBITORS

This disclosure relates to compounds that inhibit histone demethylase activity. In particular, the disclosure relates to compounds that inhibit histone lysine demethylase KDM5B, pharmaceutical compositions and methods of use, such as methods of treating cancer using the compounds and pharmaceutical compositions disclosed herein.

Copper-Catalyzed Reductive Cross-Coupling of Nonactivated Alkyl Tosylates and Mesylates with Alkyl and Aryl Bromides

A copper-catalyzed reductive cross-coupling reaction of nonactivated alkyl tosylates and mesylates with alkyl and aryl bromides was developed. It provides a practical method for efficient and cost-effective construction of aryl-alkyl and alkyl-alkyl C=C bonds with stereocontrol from readily available substrates. When used in an intramolecular fashion, the reaction enables convenient access to various substituted carbo- or heterocycles, such as 2,3-dihydrobenzofuran and benzochromene derivatives.

Processes for the preparation of (R)-alpha-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol"

The present invention provides various processes for the preparation of (R)-±-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol. These processes may be characterized by the following scheme: