4083-33-4

Basic information

• Product Name: 2-methyl-4-(4-trifluoromethyl-benzylidene)-4H-oxazol-5-one
• CAS NO: 4083-33-4
• Molecular Weight: 255.196
• Mol File: 4083-33-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-methyl-4-(4-trifluoromethyl-benzylidene)-4H-oxazol-5-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-methyl-4-(4-trifluoromethyl-benzylidene)-4H-oxazol-5-one(4083-33-4)
• EPA Substance Registry System: 2-methyl-4-(4-trifluoromethyl-benzylidene)-4H-oxazol-5-one(4083-33-4)

Safety Data

• Hazardous Substances Data: 4083-33-4(Hazardous Substances Data)

Upstream product

• 123-11-5 4-methoxy-benzaldehyde 
• 543-24-8 N-acetylglycine 

Downstream Products

• 745018-58-0 2-hydroxy-3-(4-(trifluoromethyl)phenyl)acrylic acid 
• 1627500-60-0 (Z)-2-(1,1-di-chloropentyl)-5-(4-(trifluoromethyl)benzylidene)oxazolidin-4-one 
• 82337-58-4 2-acetamido-3-(4-(trifluoromethyl)phenyl)propanoic acid 
• 14091-16-8 4-(trifluoromethyl)-dl-phenylalanine 
• 3094-34-6 2-acetamido-3-(4-(trifluoromethyl)phenyl)acrylic acid 

Relevant articles and documents

5-Benzylidene-4-oxazolidinones potently inhibit biofilm formation in Methicillin-resistant Staphylococcus aureus

Investigation into the biological function of 5-benzylidene-4-oxazolidinones revealed dose-dependent inhibition of biofilm formation in Methicillin-resistant S. aureus (MRSA). This structurally unusual class of small molecules inhibit up to 89% of biofilm formation with IC50 values as low as 0.78 μM, and disperse pre-formed biofilms with IC50 values as low as 4.7 μM. Together, these results suggest that 4-oxazolidinones represent new chemotypes to enable the study of bacterial biofilms with small molecule chemical probes.