40843-73-0Relevant articles and documents
Evaluation of the Elbs Persulfate Oxidation Reaction for the Preparation of Aryloxyphenoxypropionate Herbicides
Watson, Keith G.,Serban, Alexander
, p. 1503 - 1510 (1995)
A new, simple method for the preparation of several 4-(aryloxy)phenols (2a-d) and alkyl 2-(4-hydroxyphenoxy)propionates (3a,b) is described.These compounds are key precursors for the synthesis of important aryloxyphenoxypropionate herbicides (1a-d).The method uses the Elbs persulfate oxidation to convert phenol into 4-hydroxyphenyl sulfate (5).The free hydroxy group is then reacted with various aryl halides and alkyl 2-halopropionates.Mild hydrolysis of the sulfate group with boiling acetic acid then gives the products (2a-d) and (3a,b), generally in modest to good yield.
4-Phenoxy-phenoxy-alkane-carboxylic acid derivatives and process for their manufacture
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, (2008/06/13)
Novel 4-phenoxy-phenoxy-alkane-carboxylic acid derivatives of the formula I STR1 in which R1 stands for hydrogen, methylthio, cyclopentyl, cyclohexyl, phenyl, methylcyclohexyl, ethylcyclohexyl, or R1 and R3 together stand for a --CH=CH--CH=CH-- bridge or--unless at least one of the substituents R2 to R8 stands for hydrogen, or if R9 stands for a radical having at least 2 carbon atoms--for chlorine, R2 and R3, independent of one another, each stands for hydrogen, chlorine or alkyl of 1 to 4 carbon atoms, R4 stands for hydrogen, chlorine, alkyl of 1 to 4 carbon atoms, cyclopentyl, cyclohexyl, methylcyclohexyl or R3 and R4 together stand for a --CH=CH--CH=CH-- bridge, R5, R6 and R7, independent of one another, each stands for hydrogen or alkyl of 1 to 4 carbon atoms, R8 stands for hydrogen, alkyl of 1 to 4 carbon atoms or allyl, R9 stands for alkyl of 1 to 10 carbon atoms or phenyl and X stands for hydrogen, the cation of a physiologically acceptable inorganic or organic base of a hydrocarbon radical of 1 to 10 carbon atoms, having a strong action on the lipide and cholesterine metabolism and a process for their manufacture.