40853-88-1 Usage
Description
(Z)-9-Hexadecen-1-amine, also known as (Z)-9-hexadecenylamine or palmitoleylamine, is a long-chain unsaturated amine commonly found in biological organisms. It is classified as an alkene amine due to the presence of a double bond in its carbon chain. This chemical compound plays a crucial role in biological processes such as cell signaling, neurotransmission, and lipid metabolism. Additionally, (Z)-9-Hexadecen-1-amine has been found to exhibit antimicrobial and anti-inflammatory properties, making it a potential target for pharmaceutical and therapeutic applications. Its chemical structure and properties make it a valuable compound for research and development in the fields of biochemistry, medicine, and pharmacology.
Uses
Used in Pharmaceutical and Therapeutic Applications:
(Z)-9-Hexadecen-1-amine is used as an active compound for its antimicrobial and anti-inflammatory properties. It aids in the development of new drugs and therapies targeting various diseases and conditions.
Used in Biochemical Research:
(Z)-9-Hexadecen-1-amine is used as a research compound for studying its role in cell signaling, neurotransmission, and lipid metabolism. This helps in understanding the underlying mechanisms of various biological processes and the potential for developing new treatments.
Used in Medicine:
(Z)-9-Hexadecen-1-amine is used as a therapeutic agent for its potential applications in treating conditions related to inflammation and microbial infections. Its properties make it a promising candidate for the development of new medical treatments.
Used in the Cosmetics Industry:
(Z)-9-Hexadecen-1-amine can be used as an ingredient in cosmetics for its potential anti-inflammatory and antimicrobial properties, which may contribute to the development of products with skin-soothing and protective effects.
Check Digit Verification of cas no
The CAS Registry Mumber 40853-88-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 4,0,8,5 and 3 respectively; the second part has 2 digits, 8 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 40853-88:
(7*4)+(6*0)+(5*8)+(4*5)+(3*3)+(2*8)+(1*8)=121
121 % 10 = 1
So 40853-88-1 is a valid CAS Registry Number.
InChI:InChI=1/C16H33N/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17/h7-8H,2-6,9-17H2,1H3/b8-7+
40853-88-1Relevant articles and documents
Simplifying the Chemical Structure of Cationic Lipids for siRNA-Lipid Nanoparticles
Kuboyama, Takeshi,Yagi, Kaori,Naoi, Tomoyuki,Era, Tomohiro,Yagi, Nobuhiro,Nakasato, Yoshisuke,Yabuuchi, Hayato,Takahashi, Saori,Shinohara, Fumikazu,Iwai, Hiroto,Koubara-Yamada, Ayumi,Hasegawa, Kazumasa,Miwa, Atsushi
supporting information, p. 749 - 753 (2019/05/06)
We report a potent cationic lipid, SST-02 ((3-hydroxylpropyl)dilinoleylamine), which possesses a simple chemical structure and is synthesized just in one step. Cationic lipids are key components of siRNA-lipid nanoparticles (LNP), which may serve as potential therapeutic agents for various diseases. For a decade, chemists have given enhanced potency and new functions to cationic lipids along with structural complexity. In this study, we conducted a medicinal chemistry campaign pursuing chemical simplicity and found that even dilinoleylmethylamine (SST-01) and methylpalmitoleylamine could be used for the in vitro and in vivo siRNA delivery. Further optimization revealed that a hydroxyl group boosted potency, and SST-02 showed an ID50 of 0.02 mg/kg in the factor VII (FVII) model. Rats administered with 3 mg/kg of SST-02 LNP did not show changes in body weight, blood chemistry, or hematological parameters, while the AST level decreased at a dose of 5 mg/kg. The use of SST-02 avoids a lengthy synthetic route and may thus decrease the future cost of nucleic acid therapeutics.
