4100-13-4 Usage
Description
1,2,3-Thiadiazole-4-carboxylic acid is an organic compound characterized by its off-white to light yellow solid appearance. It is an active pharmaceutical intermediate, which means it serves as a key component in the synthesis of various pharmaceuticals.
Uses
Used in Pharmaceutical Industry:
1,2,3-Thiadiazole-4-carboxylic acid is used as an active pharmaceutical intermediate for the development of various medications. Its chemical properties make it a valuable building block in the synthesis of drugs targeting a wide range of medical conditions.
Used in Chemical Synthesis:
In addition to its pharmaceutical applications, 1,2,3-Thiadiazole-4-carboxylic acid is also utilized in chemical synthesis for the production of other compounds with diverse applications across different industries. Its unique structure and reactivity contribute to the creation of novel materials and products.
Check Digit Verification of cas no
The CAS Registry Mumber 4100-13-4 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,1,0 and 0 respectively; the second part has 2 digits, 1 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 4100-13:
(6*4)+(5*1)+(4*0)+(3*0)+(2*1)+(1*3)=34
34 % 10 = 4
So 4100-13-4 is a valid CAS Registry Number.
InChI:InChI=1/C3H2N2O2S/c6-3(7)2-1-8-5-4-2/h1H,(H,6,7)/p-1
4100-13-4Relevant articles and documents
Inhibition of Nonessential Bacterial Targets: Discovery of a Novel Serine O-Acetyltransferase Inhibitor
Magalh?es, Joana,Franko, Nina,Raboni, Samanta,Annunziato, Giannamaria,Tammela, P?ivi,Bruno, Agostino,Bettati, Stefano,Mozzarelli, Andrea,Pieroni, Marco,Campanini, Barbara,Costantino, Gabriele
, p. 790 - 797 (2020)
In ?-proteobacteria and Actinomycetales, cysteine biosynthetic enzymes are indispensable during persistence and become dispensable during growth or acute infection. The biosynthetic machinery required to convert inorganic sulfur into cysteine is absent in mammals; therefore, it is a suitable drug target. We searched for inhibitors of Salmonella serine acetyltransferase (SAT), the enzyme that catalyzes the rate-limiting step of l-cysteine biosynthesis. The virtual screening of three ChemDiv focused libraries containing 91 ?243 compounds was performed to identify potential SAT inhibitors. Scaffold similarity and the analysis of the overall physicochemical properties allowed the selection of 73 compounds that were purchased and evaluated on the recombinant enzyme. Six compounds displaying an IC50 a Gram-negative model organism, with one of them being able to interfere with bacterial growth via SAT inhibition.