41082-18-2

Basic information

• Product Name: N2-Cyclohexyl-2,3-pyridinediamine
• Synonyms: N2-Cyclohexyl-2,3-pyridinediamine;2-N-Cyclohexylpyridine-2,3-diamine
• CAS NO: 41082-18-2
• Molecular Formula: C₁₁H₁₇N₃
• Molecular Weight: 191.28
• Mol File: 41082-18-2.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N2-Cyclohexyl-2,3-pyridinediamine(CAS DataBase Reference)
• NIST Chemistry Reference: N2-Cyclohexyl-2,3-pyridinediamine(41082-18-2)
• EPA Substance Registry System: N2-Cyclohexyl-2,3-pyridinediamine(41082-18-2)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 41082-18-2(Hazardous Substances Data)

Upstream product

• 6298-19-7 2-chloro-3-aminopyridine 
• 108-91-8 cyclohexylamine 
• 61963-88-0 N²-cyclohexyl-3-nitro-2-aminopyridine 
• 5470-18-8 2-Chloro-3-nitropyridine 

Downstream Products

• 109446-19-7 3-acetylamino-2-(acetyl-cyclohexyl-amino)-pyridine 
• 1359972-97-6 3-cyclohexyl-2-(4-phenoxyphenyl)-3H-imidazo[4,5-b]pyridine 
• 1359972-99-8 3-cyclohexyl-2-p-tolyl-3H-imidazo[4,5-b]pyridine 
• 1359973-00-4 3-cyclohexyl-2-(4-methoxyphenyl)-3H-imidazo[4,5-b]pyridine 
• 1359973-01-5 3-cyclohexyl-2-(3-methylthiophen-2-yl)-3H-imidazo[4,5-b]pyridine 
• 1359973-02-6 3-cyclohexyl-2-(3-(ethylsulfonyl)phenyl)-3H-imidazo[4,5-b]pyridine 
• 1359973-03-7 3-cyclohexyl-2-(3,5-difluorophenyl)-3H-imidazo[4,5-b]pyridine 
• 1359973-04-8 3-cyclohexyl-2-(6-methoxypyridin-3-yl)-3H-imidazo[4,5-b]pyridine 
• 1359973-05-9 5-(3-cyclohexyl-3H-imidazo[4,5-b]pyridin-2-yl)-N,N-dimethylpyrimidin-2-amine 
• 1359973-08-2 3-cyclohexyl-2-(6-fluoro-5-methylpyridin-3-yl)-3H-imidazo[4,5-b]pyridine 
• 1359973-17-3 3-cyclohexyl-2-iodo-3H-imidazo[4,5-b]pyridine 

Relevant articles and documents

Regioselective N-alkylation of some imidazole-containing heterocycles and their in vitro anticancer evaluation

Imidazole-containing heterocycles: Imidazopyridines, imidazopyrimidines and imidazopyra-zines can exist more tautomeric forms than benzimidazoles. Their regioselectivities were determined for N-alkylations with 4-fluorobenzyl bromide under basic conditions (K2CO3) in DMF. We observed that, regioisomers were mainly formed as a mixture in this reaction and N-benzylation occurs at a higher ratio on six membered heterocycles. Their structural assignments were made with the use of two-dimensional 1H–1H NOE (nuclear overhauser effect spectroscopy, NOESY). Complementary structural information was provided by 2D-HMBC spectra of the compounds. Synthesized compounds were tested for in vitro cytotoxic activities against Human colon cancer cell line (HCT-116) and leukemia cell lines (K562 and HL-60) by MTT test. Among them, imidazopyridine analogue 10, bearing bromine atom at the C-6 position of the pyridine moiety, gave the lowest IC50 value with 6–7 μg/mL against all three cancer cell lines.

The ortho effect in pyridines. Part XI(1). Substituent effects on basicity of 2- and 4-substituted 3-aminopyridines

The substituent effects on the pKa values corresponding to the first protonation site of thirty 2- and 4-substituted 3-aminopyridines have been studied.It was found that the relative localized and delocalized effects are apparently sensitive to the variation of substituent position in the pyridine ring.An interaction of the 2-substituent with the protonation centre has mainly inductive character, whereas, the pKa values of 4-substituted 3-aminopyridines are highly affected by through-resonance.The steric effect was found to be insignificant.Keywords: substituent effects / 2- and 4-substituted 3-aminopyridines / basicity