411225-57-5

Basic information

• Product Name: (2S,3S)-1-tert-butyl 2-ethyl 3-methyl-pyrrolidine-1,2-dicarboxylate
• Synonyms: (2S,3S)-1-tert-butyl 2-ethyl 3-methyl-pyrrolidine-1,2-dicarboxylate
• CAS NO: 411225-57-5
• Molecular Weight: 257.33
• Mol File: 411225-57-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (2S,3S)-1-tert-butyl 2-ethyl 3-methyl-pyrrolidine-1,2-dicarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: (2S,3S)-1-tert-butyl 2-ethyl 3-methyl-pyrrolidine-1,2-dicarboxylate(411225-57-5)
• EPA Substance Registry System: (2S,3S)-1-tert-butyl 2-ethyl 3-methyl-pyrrolidine-1,2-dicarboxylate(411225-57-5)

Safety Data

• Hazardous Substances Data: 411225-57-5(Hazardous Substances Data)

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 77120-55-9 N-chloro-(2S,3S)-amino-3-methyl-pentanoic acid ethyl ester 

Downstream Products

• 817554-70-4 (2S,3S)-tert-butyl 2-(hydroxymethyl)-3-methylpyrrolidine-1-carboxylate 
• 148717-88-8 VM55599 
• 411225-58-6 (8S,8aS)-8-methylperhydroazolo[1,2-a]pyrazine-1,4-dione 

Relevant articles and documents

Synthetic studies toward paraherquamides E and F and related 13C-labeled putative biosynthetic intermediates: stereocontrolled synthesis of the α-alkyl-β-methylproline ring system

A substituted 2R-allyl-3S-methylproline ethyl ester suitable for elaboration to paraherquamides E, F and related 13C-labeled putative biosynthesis intermediates have been prepared efficiently in six steps and?24% overall yield. The key steps are a 5-exo-trig cyclization of a zinc enolate on an unactivated alkene and a stereocontrolled alkylation of the enolate formed from 3S-methyl-pyrrolidine-1,2R-dicarboxylic acid 1-tert-butyl ester 2-ethyl ester.