41295-65-2

Basic information

• Product Name: 4-Chloromethyl-6-methyl-chromen-2-one ,97%
• Synonyms: 4-Chloromethyl-6-methyl-chromen-2-one ,97%;4-(chloromethyl)-6-methyl-2H-chromen-2-one;4-(chloromethyl)-6-methyl-2H-1-Benzopyran-2-one
• CAS NO: 41295-65-2
• Molecular Formula: C₁₁H₉ClO₂
• Molecular Weight: 208.641
• EINECS: 200-156-0
• Mol File: 41295-65-2.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 348.3 °C at 760 mmHg
• Flash Point: 184.1 °C
• Appearance: /
• Density: 1.273 g/cm³
• CAS DataBase Reference: 4-Chloromethyl-6-methyl-chromen-2-one ,97%(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Chloromethyl-6-methyl-chromen-2-one ,97%(41295-65-2)
• EPA Substance Registry System: 4-Chloromethyl-6-methyl-chromen-2-one ,97%(41295-65-2)

Safety Data

• Safety Statements: 24/25
• Hazardous Substances Data: 41295-65-2(Hazardous Substances Data)

Upstream product

• 68747-27-3 (6-methyl-2-oxo-2H-chromen-4-yl)-acetic acid 
• 84105-42-0 4-Hydroxymethyl-6-methylcoumarin 
• 106-44-5 p-cresol 
• 638-07-3 ethyl (2-chloroaceto)acetate 
• 14002-89-2 4,6-dimethyl-chromen-2-one 
• 84096-84-4 6-methyl-2-oxo-2H-chromene-4-carbaldehyde 

Downstream Products

• 79344-61-9 4-Anilinomethyl-6-methylcoumarin 
• 79344-53-9 4-Anilinomethyl-7-methoxycoumarin 
• 129354-89-8 2-(5-methylbenzofuran-3-yl)acetic acid 
• 1011625-78-7 C₃₀H₂₆N₂O₂S 

Relevant articles and documents

Cytotoxic effects of coumarin substituted benzimidazolium salts against human prostate and ovarian cancer cells

Abstract: Coumarin and benzimidazole derivatives have individual biological activities including anticancer. In this study, we aimed to synthesize coumarin-benzimidazole hybrids in order to investigate their anticancer properties. For this purpose, six 6-substituted-4-chloromethylene coumarin derivatives were synthesized. Sixteen coumarin substituted benzimidazolium chlorides were synthesized by the reaction of 4-chloromethylene coumarin and N-benzylbenzimidazole derivatives. All of the synthesized compounds were characterized by 1H and 13C NMR, IR spectroscopic techniques and elemental analyses. Cytotoxicities of all compounds were tested by [3-(4,5-dimethylthiazole)-2-yl]-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay against human prostate (PC-3) and ovarian (A2780) cancer cells. All compounds performed significant cytotoxicities at 100μM against both cancer cell lines. Moreover, some compounds performed significant activities at 1μM against both cancer cell lines and the obtained results suggest that this type of compounds are promising candidates for the treatment of human prostate and ovarian cancers. Graphic abstract: Six 4-chloromethylenecoumarin derivatives and sixteen coumarin substituted benzimidazolium chlorides were synthesized and characterized. Cytotoxic properties of all compounds were tested against human prostate and ovarian cancer cell lines.[Figure not available: see fulltext.].

Synthesis of Coumarin-4-Ylmethyl Phosphonic Acids

New coumarin-4-ylmethylphosphonates and coumarin-4-ylmethylphosphonic acids were synthesized and tested for antiviral activity.

Synthesis and biological evaluation of coumarin-1,2,3-triazole- dithiocarbamate hybrids as potent LSD1 inhibitors

Two series of coumarin-1,2,3-triazole-dithiocarbamate hybrids were designed, synthesized and evaluated for their inhibitory activity towards lysine specific demethylase 1 (LSD1). Compounds 8a, 8d-8f, 8i-8l presented potent activity against lysine specific demethylase 1. Among them, compound 8k showed potent and reversible inhibition against lysine specific demethylase 1 with an IC50 value of 0.39 μM, which was 74-fold more potent than that of tranylcypromine (2-PCPA). Besides, compound 8k displayed excellent selectivity against lysine specific demethylase 1 without inhibition against monoamine oxidases (MAOs) A and B. Further investigation revealed that compound 8k was active at both recombinant and cell levels by upregulating the expression of H3K4me1, H3K4me2 and H3K9me2. This journal is the Partner Organisations 2014.