41297-11-4

Basic information

• Product Name: (E)-4-(4-n-butylphenyl)-4-oxo-2-butenoic acid
• Synonyms: (E)-4-(4-n-butylphenyl)-4-oxo-2-butenoic acid
• CAS NO: 41297-11-4
• Molecular Weight: 232.279
• Mol File: 41297-11-4.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (E)-4-(4-n-butylphenyl)-4-oxo-2-butenoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-4-(4-n-butylphenyl)-4-oxo-2-butenoic acid(41297-11-4)
• EPA Substance Registry System: (E)-4-(4-n-butylphenyl)-4-oxo-2-butenoic acid(41297-11-4)

Safety Data

• Hazardous Substances Data: 41297-11-4(Hazardous Substances Data)

Upstream product

• 108-31-6 maleic anhydride 
• 104-51-8 1-butylbenzene 

Downstream Products

• 1429427-91-7 (2E)-4-(4-butylphenyl)-4-oxo-N-phenyl-2-butenamide 

Relevant articles and documents

(E)-4-Aryl-4-oxo-2-butenoic acid amides, chalcone-aroylacrylic acid chimeras: Design, antiproliferative activity and inhibition of tubulin polymerization

Antiproliferative activity of twenty-nine (E)-4-aryl-4-oxo-2-butenoic acid amides against three human tumor cell lines (HeLa, FemX, and K562) is reported. Compounds showed antiproliferative activity in one-digit micromolar to submicromolar concentrations.

2-[(Carboxymethyl)sulfanyl]-4-oxo-4-arylbutanoic acids selectively suppressed proliferation of neoplastic human HeLa cells. A SAR/QSAR study

A series of twenty alkyl-, halo-, and methoxy-aryl-substituted 2-[(carboxymethyl)sulfanyl]-4-oxo-4-arylbutanoic acids were synthesized. The new compounds, called CSAB, suppressed proliferation of human cervix carcinoma, HeLa cells, in vitro in a concentration range of 0.644 to 29.48 μM/L. Two compounds exhibit antiproliferative activity in sub-micromolar concentrations (16, 19). Five compounds act in low micromolar concentrations ( 10). A strong structure-activity relationship, using estimated log P values and BCUT descriptors, was observed.