4136-37-2 Usage
Description
Stachydrine Hydrochloride, also known as Stachydrine Chloride, is a naturally occurring quaternary ammonium compound found in various plant sources, including the Chinese herb Leonurus heterophyllus Sweet. It is characterized by its potential pharmacological properties and is recognized for its ability to support blood circulation and dispel blood stasis.
Uses
Used in Traditional Chinese Medicine:
Stachydrine Hydrochloride is used as a medicinal component for enhancing blood circulation and reducing blood stasis. Its application in traditional Chinese medicine is based on its ability to improve blood flow and alleviate conditions associated with poor circulation.
Used in Clinical Applications:
Stachydrine Hydrochloride is utilized as a therapeutic agent in clinics to support blood circulation and dispel blood stasis. Its clinical use is attributed to its effectiveness in treating conditions related to impaired blood flow and blood stasis, which can contribute to various health issues.
Biological Activity
stachydrine is an anti-metastatic agent.stachydrine, a pyrrolidine betaine, was first isolated from seed husk and the pulp of the fruit of c. leonurus, and many other asian plants and fruits.
in vitro
the aim of a previous study was to investigate the effects of stachydrine (sta) on norepinephrine (ne) induced hypertrophy and the changes of calcium transients in neonatal rat cardiomyocytes. results showed that ne treatment could increase protein synthesis, cell surface area, the expression level of β-mhc and β/α-mhc ratio and these effects were attenuated by sta treatment. in addition, ne-induced hypertrophy was associated with accelerated decay of ca2+-transient, increased phospholamban expression, increased ca2+-transient amplitude, hyper-phosphorylation, increased intracellular camp level, as well as pka overactivation. all of these effects could be inhibited by sta treatment significantly [1].
in vivo
previous study evaluated the effect of stachydrine on the expression of caspase-9 and 12 in rats with unilateral ureteral obstruction. results showed that degree of renal interstitial fibrosis, serum creatinine, blood urea nitrogen, the renal tubular interstitial damage index, and expression of caspase-9 and 12 in the stachydrine-treatment groups were significantly decreased [2].
references
[1] zhang, c. ,shan, x.-l.,liao, y.-l., et al. effects of stachydrine on norepinephrine-induced neonatal rat cardiac myocytes hypertrophy and intracellular calcium transients. bmc complement. altern. med. 14, 474 (2014).[2] zhang c, lu y, zhou yj, tong qq, qu c, kang tj. the effect of stachydrine on the expression of caspase-12 in rats with unilateral ureteral obstruction. j urol. 2014 nov;192(5):1549-54.
Check Digit Verification of cas no
The CAS Registry Mumber 4136-37-2 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,1,3 and 6 respectively; the second part has 2 digits, 3 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 4136-37:
(6*4)+(5*1)+(4*3)+(3*6)+(2*3)+(1*7)=72
72 % 10 = 2
So 4136-37-2 is a valid CAS Registry Number.
InChI:InChI=1/C7H13NO2.ClH/c1-8(2)5-3-4-6(8)7(9)10;/h6H,3-5H2,1-2H3;1H