41419-25-4

Basic information

• Product Name: 6-phenylpiperidin-2-one
• Synonyms: 6-phenylpiperidin-2-one;6-Phenyl-2-piperidone
• CAS NO: 41419-25-4
• Molecular Formula: C₁₁H₁₃NO
• Molecular Weight: 175
• Mol File: 41419-25-4.mol
• Article Data: 15

Chemical Properties

• Melting Point: 141-142℃ (benzene ligroine )
• Appearance: /
• Density: 1.073±0.06 g/cm3 (20 ºC 760 Torr)
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 6-phenylpiperidin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 6-phenylpiperidin-2-one(41419-25-4)
• EPA Substance Registry System: 6-phenylpiperidin-2-one(41419-25-4)

Safety Data

• Hazardous Substances Data: 41419-25-4(Hazardous Substances Data)

Usage

General Description

6-phenylpiperidin-2-one, also known as benzyl piperidone, is a chemical compound with the molecular formula C13H15NO. It is a white to off-white crystalline powder that is commonly used as an intermediate in the synthesis of pharmaceuticals and other organic compounds. 6-phenylpiperidin-2-one is also used in the production of dyes, pigments, and as a flavor and fragrance ingredient. It is a versatile building block in organic chemistry, and its derivatives have applications in a wide range of industries. The compound is known for its strong odor, and it is important to handle it with care, following all applicable safety guidelines and regulations.

Upstream product

• 1501-04-8 Methyl 4-benzoylbutanoate 
• 77287-34-4 formamide 
• 934520-52-2 5-hydroxyimino-5-phenylpentanoic acid methyl ester 
• 461383-67-5 S-(2-iodophenethyl) 5-azido-5-phenylpentanethioate 
• 1501-05-9 5-oxo-5-phenylvaleric acid 
• 263750-46-5 methyl 5-bromo-5-phenylpentanoate 
• 461383-60-8 methyl 5-azido-5-phenylpentanoate 
• 20620-59-1 5-phenyl-n-valeric acid methyl ester 
• 2270-20-4 5-Phenylpentanoic acid 
• 461383-62-0 5-azido-5-phenylpentanoyl chloride 
• 461383-61-9 5-azido-5-phenylpentanoic acid 
• 91247-40-4 5-amino-5-phenylpentanoic acid 
• 1006713-41-2 ethyl 5-phenyl-5-N-(2-pyridylsulfonylamino)pentanoate 
• 101584-93-4 benzyl-(3-hydroxy-1-phenylpropyl)carbamate 

Downstream Products

• 109758-37-4 1-{3-[4-(2-Oxo-2-pyrrolidin-1-yl-ethyl)-piperazin-1-yl]-propyl}-6-phenyl-piperidin-2-one; compound with oxalic acid 
• 109758-38-5 1-{1-[3-(2-Oxo-6-phenyl-piperidin-1-yl)-propyl]-piperidin-4-yl}-1,3-dihydro-benzoimidazol-2-one; compound with oxalic acid 

Relevant articles and documents

Method for synthesizing lactam derivative without catalyst

The invention discloses a simple synthesis method for a lactam derivative. The method comprises the step that with formamide as an amine source and a hydrogen donor (hydrolyzed to produce formic acid)and keto acid as raw materials, the lactam derivative is easily synthesized through a cycloamination reaction without a solvent or a catalyst. Compared with previous reports, the time required for the reaction is greatly shortened, the selectivity is remarkably improved, the conversion rate of the keto acid derivative is 99%, and the yield of the lactam derivative can reach 70-94%.

An Efficient Two-Step Preparation of α-, β-, γ- or δ-Amino Acids from 2-Pyrazinones, 2-Hydroxypyrimidines or 2-Pyridones Respectively

A practical and efficient two-step procedure is reported for the preparation of a variety of α-, β-, γ- and δ-amino acids from 2-pyridone, 2-pyrazinone or 2-hydroxypyrimidine and derivatives. The procedure is amenable to scale-up and in most cases no chromatographic purification of the product is required. This approach is useful, especially in the synthesis of amino acids or deuterated amino acids that are not obtained by other methods.

Stereoselective nucleophilic addition reactions to cyclic n-acyliminium ions using the indirect cation pool method: Elucidation of stereoselectivity by spectroscopic conformational analysis and dft calculations

In this study, six-membered N-acyliminium ions were generated by the “indirect cation pool” method and reacted with several nucleophiles. These reactions afforded disubstituted piperidine derivatives with high diastereoselectivities and good to excellent