41839-60-5

Basic information

• Product Name: Benzenemethanimine, 4-chloro-a-phenyl-
• CAS NO: 41839-60-5
• Molecular Formula: C13H10ClN
• Molecular Weight: 215.682
• Mol File: 41839-60-5.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Benzenemethanimine, 4-chloro-a-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenemethanimine, 4-chloro-a-phenyl-(41839-60-5)
• EPA Substance Registry System: Benzenemethanimine, 4-chloro-a-phenyl-(41839-60-5)

Safety Data

• Hazardous Substances Data: 41839-60-5(Hazardous Substances Data)

Upstream product

• 163837-32-9 (S)-4-chloro-α-phenyl-benzenemethanamine 
• 28022-43-7 p-chlorobenzhydrylamine 
• 106-39-8 bromochlorobenzene 
• 100-47-0 benzonitrile 
• 623-03-0 4-Cyanochlorobenzene 
• 100-58-3 phenylmagnesium bromide 

Downstream Products

• 112120-95-3 2-(4-Chloro-phenyl)-2-phenyl-4,5-di-p-tolyl-2,5-dihydro-oxazole 
• 81724-87-0 2-(p-chlorophenyl)-2,4,5-triphenyl-3-oxazoline 
• 134-85-0 4-chlorobenzophenone 
• 28022-43-7 p-chlorobenzhydrylamine 
• 69414-87-5 (4-chloro-benzhydrylidene)-(morpholin-4-yl-phenyl-methyl)-amine 
• 69414-85-3 (4-methyl-benzhydrylidene)-(morpholin-4-yl-phenyl-methyl)-amine 
• 69414-84-2 (4-chloro-benzhydrylidene)-morpholin-4-ylmethyl-amine 

Relevant articles and documents

Copper-catalyzed [2+3]-annulation of N-H imines with vinyl azides: Access to polyaryl 2: H -imidazoles

A practical method for the synthesis of 2H-imidazoles via a [2+3] annulation of N-H imines with vinyl azides using a copper catalyst is developed. In this conversion, environmentally friendly oxygen is used as the sole oxidant and N2 and H2O are the only by-products. The catalytic transformation, operating under mild conditions, is operationally simple and is considered as a readily available catalytic system having good substrate and functional compatibility with high atom-efficiency without the need for additional ligands or additives.

Expansion of the Substrate Specificity of Porcine Kidney D-Amino Acid Oxidase for S-Stereoselective Oxidation of 4-Cl-Benzhydrylamine

Discovery and development of enzymes for the synthesis of chiral amines have been a hot topic for basic and applied aspects of biocatalysts. Based on our X-ray crystallographic analyses of porcine kidney D-amino acid oxidase (pkDAO) and its variants, we rationally designed a new variant that catalyzed the oxidation of (S)-4-Cl-benzhydrylamine (CBHA) from pkDAO and obtained it by functional high-throughput screening with colorimetric assay. The variant I230A/R283G was constructed from the variant R283G which had completely lost the activity for D-amino acids, further gaining new activity toward (S)-chiral amines with the bulky substituents. The variant enzyme (I230A/R283G) was characterized to have a catalytic efficiency of 1.85 s?1 for (S)-CBHA, while that for (R)-1-phenylethylamine was diminished 10-fold as compared with the Y228L/R283G variant. The variant was efficiently used for the synthesis of (R)-CBHA in 96 % ee from racemic CBHA by the deracemization reaction in the presence of reducing agent such as NaBH4 in water. Furthermore, X-ray crystallographic analysis of the new variant complexed with (S)-CBHA, together with modelling study clearly showed the basis of understanding the structure-activity relationship of pkDAO.