41873-72-7

Basic information

• Product Name: 2H-CHROMENE-3-CARBONYL CHLORIDE
• Synonyms: 2H-CHROMENE-3-CARBONYL CHLORIDE;2H-1-Benzopyran-3-carbonyl chloride (9CI)
• CAS NO: 41873-72-7
• Molecular Formula: C₁₀H₇ClO₂
• Molecular Weight: 194.61
• Product Categories: ACIDHALIDE
• Mol File: 41873-72-7.mol
• Article Data: 5

Chemical Properties

• Melting Point: 67℃
• Boiling Point: 309.6°Cat760mmHg
• Flash Point: 115.1°C
• Appearance: /
• Density: 1.344g/cm³
• Vapor Pressure: 0.000634mmHg at 25°C
• Refractive Index: 1.593
• CAS DataBase Reference: 2H-CHROMENE-3-CARBONYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2H-CHROMENE-3-CARBONYL CHLORIDE(41873-72-7)
• EPA Substance Registry System: 2H-CHROMENE-3-CARBONYL CHLORIDE(41873-72-7)

Safety Data

• Hazard Codes: Xn
• Statements: 22-36
• Safety Statements: 26
• Hazardous Substances Data: 41873-72-7(Hazardous Substances Data)

Usage

Classification

Chromene derivative

Structure

Contains a chromene ring with a carbonyl group at the 3-position

Use

Organic synthesis, reagent in chemical reactions

Application

Production of pharmaceuticals, agrochemicals, and other fine chemicals

Versatility

Known for versatile reactivity

Intermediate

Used in the synthesis of biologically active compounds and heterocyclic molecules

InChI:InChI=1/C10H7ClO2/c11-10(12)8-5-7-3-1-2-4-9(7)13-6-8/h1-5H,6H2

Upstream product

• 22649-28-1 2H-chromene-3-carboxylic acid 
• 90-02-8 salicylaldehyde 
• 151510-35-9 tert-butyl 2H-1-chromene-3-carboxylate 
• 57543-66-5 2H-chromene-3-carbonitrile 
• 10185-00-9 Chromene-3-carboxamide 

Downstream Products

• 83823-26-1 (2H-Chromen-3-yl)-(4-methyl-piperazin-1-yl)-methanone 
• 83823-11-4 2H-Chromene-3-carboxylic acid pyridin-3-ylamide 
• 83823-09-0 (2H-Chromen-3-yl)-(4-phenyl-piperazin-1-yl)-methanone 
• 83823-27-2 (2H-Chromen-3-yl)-[4-(2-methoxy-phenyl)-piperazin-1-yl]-methanone 
• 83823-12-5 (2H-Chromen-3-yl)-(2-imino-2H-pyridin-1-yl)-methanone 
• 83823-10-3 2H-Chromene-3-carboxylic acid phenethyl-amide 
• 83823-14-7 2H-Chromene-3-carboxylic acid diethylamide 
• 83823-18-1 2H-Chromene-3-carboxylic acid butylamide 
• 83823-16-9 2H-Chromene-3-carboxylic acid (2-diethylamino-ethyl)-amide 
• 83823-15-8 2H-Chromene-3-carboxylic acid (2-hydroxy-2-phenyl-ethyl)-amide 
• 83823-44-3 1-Chroman-3-ylmethyl-4-phenyl-piperazine 
• 83823-37-4 1-(2H-Chromen-3-ylmethyl)-4-phenyl-piperazine 
• 83823-35-2 1-(2H-Chromen-3-ylmethyl)-4-(2-methoxy-phenyl)-piperazine 
• 83823-39-6 (2H-Chromen-3-ylmethyl)-diethyl-amine; hydrochloride 

Relevant articles and documents

Ruthenium-Catalyzed Oxidative Annulation and Hydroarylation of Chromene-3-carboxamides with Alkynes via Double C-H Functionalization

Ruthenium-catalyzed oxidative annulation of 2H-chromene-3-carboxamides with alkynes has been achieved by using the directing group nature of amide in the presence of Cu(OAc)2·H2O as an oxidant and AgNTf2 as an additive. This reaction offers a broad substrate scope, and both symmetrical and unsymmetrical alkynes can be harnessed. High regioselectivity was achieved in the case of unsymmetrical alkynes. In addition, we have also accomplished double C-H activation by employing an excess of alkyne, where both annulation and hydroarylation took place regio- and stereoselectively in one pot, with the catalyst playing a dual role. While the first C-H functionalization could involve Ru-N covalent bond, the second C-H functionalization most likely involves Ru-O coordinate bond. The structures of key products are confirmed by X-ray crystallography.

Substituted chromenes as potent, orally active 5-lipoxygenase inhibitors

A series of chromene derivatives was synthesized and evaluated for their in vitro and ex vivo 5-lipoxygenase (5-LO) inhibitory activity. These compounds were prepared by condensation of appropriate salicyl aldehydes with α,β-unsaturated carbonyl compounds

Chromene and Chroman 3-Carboxamides and Some Related Compounds as a New Class of Centrally Acting Agents

A number of chromene-3-carboxamides (7), 3-Aminochromans (11) and 3-aminomethylchromans (9) have been synthesized.Chromene-3-carboxamides have been found to exhibit strong central muscle relaxant activity compared to mephesin.