41938-15-2

Basic information

• Product Name: methyl N-(tert-butoxycarbonyl)alanylthreoninate
• CAS NO: 41938-15-2
• Molecular Formula: C₁₃H₂₄N₂O₆
• Molecular Weight: 304.3395
• Mol File: 41938-15-2.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 501.2°C at 760 mmHg
• Flash Point: 256.9°C
• Density: 1.154g/cm³
• Vapor Pressure: 3.81E-12mmHg at 25°C
• Refractive Index: 1.476
• CAS DataBase Reference: methyl N-(tert-butoxycarbonyl)alanylthreoninate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl N-(tert-butoxycarbonyl)alanylthreoninate(41938-15-2)
• EPA Substance Registry System: methyl N-(tert-butoxycarbonyl)alanylthreoninate(41938-15-2)

Safety Data

• Hazardous Substances Data: 41938-15-2(Hazardous Substances Data)

Upstream product

• 3373-59-9 L-threonine methyl ester 
• 54430-64-7 [(1S)-2-imidazol-1-yl-1-methyl-2-oxo-ethyl]-carbamic acid tert-butyl ester 
• 15761-38-3 L-N-Boc-Ala 
• 39994-75-7 L-threonine methyl ester hydrochloride 
• 2483-49-0 tert-butyloxycarbonyl-L-alanine p-nitrophenyl ester 

Relevant articles and documents

In pursuit of balgacyclamide A – Discovery of an oxazoline macrocycle with multiple myeloma cytotoxicity and penetration

Four new oxazoline based macrocycles have been constructed, said cycles were found to possess varying cytotoxicity against six different cancer cell lines: IC50 values of 6.4 μM towards HeLa and 11.9 μM towards LnCaP being the most potent. Two of the four macrocycles were found to have marginal cytotoxicity against MM.1S and MM.1R, myeloma cancer cell lines, and further evaluation showed that they also possessed rapid cellular uptake and accumulation characteristics. Through the structure-activity relationship comparisons between the four compounds, it was found that the C6 position of the E-ring is amendable to substitution and could possibly serve as a conjugation site for the development of a selective delivery system to MM.1R.

PYRAZOLOPYRIMIDINE COMPOUNDS AND THEIR USE AS PDE10 INHIBITORS

The present invention relates to a compound represented by formula [I]: wherein: R1 is hydrogen, halogen, lower alkyl or cyano; Ring A is an optionally substituted heterocyclic group; Ring B is an optionally substituted 3 to 6-membered monocyclic group; and Y is optionally substituted amino, optionally substituted cyclic amino, optionally substituted aliphatic 3 to 6-membered monocyclyloxy, optionally substituted lower alkyl or optionally substituted lower alkyl-O-, or a pharmaceutically acceptable salt thereof, and to their use as PDE10 inhibitor.

KINETICS OF ACYL TRANSFER IN PEPTIDE SYNTHESIS. I. ROLE OF IMIDAZOLE IN TRANSFER REACTIONS OF AN AMINOACYL GROUP FROM p-NITROPHENYL ESTERS OF N-PROTECTED AMINOACIDS TO AMINO ACID ESTERS

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