41994-51-8 Usage
Description
H-DL-TIC-OH, also known as 1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid, is an organic compound with potential applications in various fields. It is a derivative of isoquinoline, a heterocyclic compound with a bicyclic structure consisting of a six-membered aromatic ring fused to a five-membered nitrogen-containing ring. Its chemical structure allows it to interact with various biological targets and exhibit different pharmacological properties.
Uses
Used in Pharmaceutical Industry:
H-DL-TIC-OH is used as a key intermediate in the synthesis of various pharmaceutical compounds, including 10,10a-dihydroimidazo-[1,5-b]isoquinoline-1,3(2H,5H)-diones. These compounds have potential applications as inhibitors of inflammation, apoprotein B-100 biosynthesis, and matrix-degrading metalloproteases. They can be used for the treatment of various inflammatory and metabolic disorders, as well as for the development of novel therapeutic agents targeting cancer and other diseases.
Used in Medicinal Chemistry Research:
H-DL-TIC-OH can be used as a building block in the design and synthesis of new bioactive molecules with potential therapeutic applications. Its unique chemical structure allows for the development of novel drug candidates with improved pharmacological properties, such as enhanced potency, selectivity, and reduced side effects.
Used in Chemical Synthesis:
H-DL-TIC-OH can be employed as a versatile synthetic building block in the preparation of various organic compounds, including pharmaceuticals, agrochemicals, and other specialty chemicals. Its reactivity and functional groups enable the formation of a wide range of chemical products through various synthetic routes and reactions.
Check Digit Verification of cas no
The CAS Registry Mumber 41994-51-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 4,1,9,9 and 4 respectively; the second part has 2 digits, 5 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 41994-51:
(7*4)+(6*1)+(5*9)+(4*9)+(3*4)+(2*5)+(1*1)=138
138 % 10 = 8
So 41994-51-8 is a valid CAS Registry Number.
InChI:InChI=1/C10H11NO2.ClH/c12-10(13)9-5-7-3-1-2-4-8(7)6-11-9;/h1-4,9,11H,5-6H2,(H,12,13);1H
41994-51-8Relevant articles and documents
Novel bifunctional alkylating agents, 5,10-dihydropyrrolo[1,2-b] isoquinoline derivatives, synthesis and biological activity
Chaniyara, Ravi,Kapuriya, Naval,Dong, Huajin,Lee, Pei-Chih,Suman, Sharda,Marvania, Bhavin,Chou, Ting-Chao,Lee, Te-Chang,Kakadiya, Rajesh,Shah, Anamik,Su, Tsann-Long
experimental part, p. 275 - 286 (2011/02/27)
A series of linear pyrrolo[1,2-b]isoquinoline derivatives was synthesized for antitumor evaluation. The preliminary antitumor studies reveal that both bis(hydroxymethyl) and their bis(alkylcarbamate) derivatives show significant antitumor activity in inhibiting various human tumor cell growth in vitro. 1,2-Bis(hydroxymethyl)-3-methyl-5,10-dihydropyrrolo[1,2-b]isoquinoline (20a) was selected for antitumor studies in animal models. The results show that this agent can induce complete tumor remission or significant suppression in nude mice bearing human breast (MX-1) xenograft and ovarian (SK-OV-3) xenografts, respectively. Alkaline agarose gel shifting assay showed that 20a is able to cross-link with DNA. Studies on the cell cycle inhibition revealed that this agent induces cell arrest at G2/M phase. The results warrant further antitumor investigation against other human tumor growth in animal models.
