42075-21-8 Usage
Description
4-(3-Cyano-2-methylpropionyl)acetamilide, also known as N-(4-(3-Cyano-2-methylpropanoyl)phenyl)acetamide, is an organic compound that serves as a crucial intermediate in the pharmaceutical industry. It is characterized by its unique chemical structure, which includes a cyano group, a methyl group, and an amide group, all attached to a central phenyl ring. This structure endows it with specific properties that make it valuable in the development of certain medications.
Uses
Used in Pharmaceutical Industry:
4-(3-Cyano-2-methylpropionyl)acetamilide is used as a key intermediate in the synthesis of pimobendan monohydrate, a cardiotonic agent. Pimobendan is a medication that helps to improve the contractility of the heart, making it particularly useful in the treatment of congestive heart failure and certain cardiac conditions. The unique chemical structure of 4-(3-Cyano-2-methylpropionyl)acetamilide plays a vital role in the development of this life-saving drug, contributing to its effectiveness and therapeutic potential.
Synthesis Reference(s)
The Journal of Organic Chemistry, 38, p. 4044, 1973 DOI: 10.1021/jo00987a019
Check Digit Verification of cas no
The CAS Registry Mumber 42075-21-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 4,2,0,7 and 5 respectively; the second part has 2 digits, 2 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 42075-21:
(7*4)+(6*2)+(5*0)+(4*7)+(3*5)+(2*2)+(1*1)=88
88 % 10 = 8
So 42075-21-8 is a valid CAS Registry Number.
42075-21-8Relevant articles and documents
Studies on agents with vasodilator and β-blocking activities. IV
Seki, Toshimi,Nakao, Tomio,Masuda, Takeshi,Hasumi, Kohichi,Gotanda, Kotaro,Ishimori, Tsutomu,Honma, Seijiro,Minami, Nobuyoshi,Shibata, Kenyu,Yasuda, Kikuo
, p. 2061 - 2069 (2007/10/03)
A series of novel pyridazinone derivatives (II) having a phenoxypropanolamine moiety was synthesized. Their hypotensive and β- blocking activities were evaluated after intravenous administration of the compounds to anesthetized rats. Among them, the 5-chloro-2-cyanophenoxy derivative (29) showed the promising dual activities and was selected for further studies.
