42186-06-1

Basic information

• Product Name: 2-(4-broMophenyl)propanenitrile
• Synonyms: 2-(4-broMophenyl)propanenitrile;2-(4-BroMo-phenyl)-propionitrile
• CAS NO: 42186-06-1
• Molecular Formula: C₉H₈BrN
• Molecular Weight: 210.07052
• Mol File: 42186-06-1.mol
• Article Data: 20

Chemical Properties

• Boiling Point: 293.3±15.0 °C(Predicted)
• Appearance: /
• Density: 1.409±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 2-(4-broMophenyl)propanenitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-broMophenyl)propanenitrile(42186-06-1)
• EPA Substance Registry System: 2-(4-broMophenyl)propanenitrile(42186-06-1)

Safety Data

• Hazardous Substances Data: 42186-06-1(Hazardous Substances Data)

Usage

Synthesis Reference(s)

The Journal of Organic Chemistry, 42, p. 3114, 1977 DOI: 10.1021/jo00439a002

Upstream product

• 38622-91-2 [(p-methylphenyl)sulfonylmethyl]isonitrile 
• 99-90-1 para-bromoacetophenone 
• 16532-79-9 4-Bromophenylacetonitrile 
• 616-38-6 carbonic acid dimethyl ester 
• 7677-24-9 trimethylsilyl cyanide 
• 5391-88-8 1-(4-bromophenyl)ethanol 
• 74-88-4 methyl iodide 
• 2039-82-9 1-bromo-4-ethenyl-benzene 
• 75-86-5 2-hydroxy-2-methylpropanenitrile 
• 68-12-2 N,N-dimethyl-formamide 
• 159755-11-0 1-bromo-4-(1-bromoethyl)benzene 
• 124-38-9 carbon dioxide 
• 67-56-1 methanol 

Downstream Products

• 256381-13-2 2-(4-bromophenyl)propan-1-amine 
• 362061-49-2 (R)-(-)-2-(4'-bromophenyl)propionamide 
• 156143-00-9 (S)-(+)-2-(4'-bromophenyl)propanoic acid 
• 156142-98-2 (R)-(-)-2-(4'-bromophenyl)propanoic acid 
• 156143-26-9 (R)-(-)-tropanyl 2-(4'-bromophenyl)propionate 
• 156143-26-9 (S)-(+)-tropan-3-yl 2-(4'-bromophenyl)propionate 
• 211315-22-9 N-2-(4-(thien-3-yl)phenyl)propyl amine 
• 211311-65-8 propane-2-sulfonic acid (2-(4-bromo-phenyl)-propyl)-amide 
• 211314-91-9 1-[(1-tert-butoxycarbonylamino-1-methyl)ethyl]-4-bromobenzene 
• 211315-23-0 2-(4-(3-Thienyl)phenyl)-N-(t-butyloxycarbonyl)propyl Amine 
• 211311-95-4 LY 404187 
• 53086-53-6 2-(4-bromophenyl)propionic acid 

Relevant articles and documents

Rhenium(I)-Catalyzed C-Methylation of Ketones, Indoles, and Arylacetonitriles Using Methanol

A ReCl(CO)5/MeC(CH2PPh2)3 (L2) system was developed for the C-methylation reactions utilizing methanol and base, following the borrowing hydrogen strategy. Diverse ketones, indoles, and arylacetonitriles underwent mono-and dimethylation selectively up to 99% yield. Remarkably, tandem multiple methylations were also achieved by employing this catalytic system.

α-Methylation of 2-Arylacetonitrile by a Trimethylamine-Borane/CO2 System

A highly selective monomethylation of 2-arylacetonitrile using CO2 is described. The utilization of trimethylamine-borane facilitates the six-electron reduction of CO2. This reaction is the first selective six-electron reductive functionalization of CO2 faciliated by C(sp3)-H bonds. A variety of 2-arylpropionitrile was obtained in good yields. The reaction could also be applied at the gram scale.

Phenanthrene Synthesis by Palladium(II)-Catalyzed γ-C(sp2)-H Arylation, Cyclization, and Migration Tandem Reaction

Phenanthrene is an important structural motif in chemistry and materials science, and many synthetic routes have been developed to construct its skeleton. However, synthesis of unsymmetric phenanthrenes remains a challenge. Here, an efficient one-pot tandem reaction for the preparation of phenanthrenes via sequential γ-C(sp2)-H arylation, cationic cyclization, dehydration, and 1,2-migration was developed. A wide range of symmetric and unsymmetric phenanthrenes with diversified functional groups were synthesized with good to excellent yields.