42308-20-3

Basic information

• Product Name: Propanamide, 2-bromo-N-phenyl-
• CAS NO: 42308-20-3
• Molecular Formula: C₉H₁₀BrNO
• Molecular Weight: 228.088
• Mol File: 42308-20-3.mol
• Article Data: 17

Chemical Properties

• Boiling Point: 353.3°Cat760mmHg
• Flash Point: 167.5°C
• Density: 1.494g/cm³
• CAS DataBase Reference: Propanamide, 2-bromo-N-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Propanamide, 2-bromo-N-phenyl-(42308-20-3)
• EPA Substance Registry System: Propanamide, 2-bromo-N-phenyl-(42308-20-3)

Safety Data

• Hazardous Substances Data: 42308-20-3(Hazardous Substances Data)

Usage

General Description

Propanamide, 2-bromo-N-phenyl- is an organic compound with the chemical formula C9H10BrNO. It is an amide derivative, with a phenyl and a bromine group attached to the nitrogen atom. This chemical is often used as an intermediate in organic synthesis and is commonly used in the production of pharmaceuticals and agrochemicals. It is a white crystalline solid that is slightly soluble in water and has a melting point of around 83-85°C. 2-bromo-N-phenylpropanamide is also used as a building block for various organic reactions and is an important compound in the field of medicinal chemistry.

Upstream product

• 60-29-7 diethyl ether 
• 563-76-8 α-bromopropionyl bromide 
• 62-53-3 aniline 
• 103-84-4 Acetanilid 
• 71-43-2 benzene 
• 7148-74-5 2-Bromopropionyl chloride 
• 598-72-1 2-Bromopropionic acid 

Downstream Products

• 102182-36-5 N-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-alanin-anilide 
• 101089-96-7 2-phenoxy-propionic acid anilide 
• 77868-73-6 3,6-dimethyl-1,4-diphenyl-piperazine-2,5-dione 
• 620-71-3 N-(phenyl)-2-methylacetamide 
• 21262-52-2 2-chloro-N-phenylpropanamide 

Relevant articles and documents

Unbalanced-Ion-Pair-Catalyzed Nucleophilic Fluorination Using Potassium Fluoride

An unbalanced ion pair promoter (e.g., tetrabutylammonium sulfate), consisting of a bulky and charge-delocalized cation and a small and charge-localized anion, greatly accelerates nucleophilic fluorinations using easy handling KF. We also successfully converted an inexpensive and commercially available ion-exchange resin to the polymer-supported ion pair promoter (A26–SO42–), which could be reused after filtration. Moreover, A26–SO42– can be used in continuous flow conditions. In our conditions, water is well-tolerated.

Comparative conventional and microwave assisted synthesis of heterocyclic oxadiazole analogues having enzymatic inhibition potential

A comparative microwave assisted and conventional synthetic strategies were applied to synthesize heterocyclic 1,3,4-oxadiazole analogues as active anti-enzymatic agents. Green synthesis of compound 1 was achieved by stirring 4-methoxybenzenesulfonyl chloride (a) and ethyl piperidine-4-carboxylate (b). Compound 1 was converted into respective hydrazide (2) by hydrazine and then into 1,3,4-oxadiazole (3) by CS2 on reflux. The electrophiles, N-alkyl/aralkyl/aryl-2-bromopropanamides (6a–p) were synthesized and converted to N-alkyl/aralkyl/aryl-2-propanamide derivatives (7a–p) by reaction with 3 under green chemistry. Microwave assisted method was found to be effective relative to conventional method. 13C-NMR, 1H-NMR and IR techniques were availed to corroborate structures of synthesized compounds and then subjected to screening against lipoxygenase (LOX), α-glucosidase, acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes. A number of compounds presented better potential against these enzymes. The most active compounds against LOX and α-glucosidase enzymes were subjected to molecular docking study to explore their interactions with the active sites of the enzymes.

A transition metal-free approach to a regioselective total synthesis of the natural product derivative 6-methylellipticine, a potent anticancer agent

A transition metal-free and regioselective total synthesis of 6-methylellipticine, a potent anticancer agent, was developed. This synthetic approach mainly involved two key reactions: a direct amination of multi-functional phenol via an alkylation-Smiles