423180-28-3

Basic information

• Product Name: 4-chloro-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinoline-3-carbonitrile
• Synonyms: 4-chloro-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinoline-3-carbonitrile
• CAS NO: 423180-28-3
• Molecular Weight: 345.829
• Mol File: 423180-28-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-chloro-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinoline-3-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 4-chloro-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinoline-3-carbonitrile(423180-28-3)
• EPA Substance Registry System: 4-chloro-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinoline-3-carbonitrile(423180-28-3)

Safety Data

• Hazardous Substances Data: 423180-28-3(Hazardous Substances Data)

Upstream product

• 20691-89-8 1-methyl-4-piperidinemethanol 
• 263149-10-6 4-chloro-7-hydroxy-6-methoxyquinolin-3-carbonitrile 

Relevant articles and documents

Investigation of the effect of varying the 4-anilino and 7-alkoxy groups of 3-quinolinecarbonitriles on the inhibition of Src kinase activity

Several 7-alkoxy-4-anilino-3-quinolinecarbonitriles were synthesized and evaluated for Src kinase inhibitory activity. Optimal inhibition of both Src enzymatic and cellular activity was seen with analogues having a 2,4-dichloro-5-methoxyaniline group at C-4. Compound 18, which has a 1-methylpiperidinemethoxy group at C-7, showed in vivo activity in a xenograft model.