423737-44-4Relevant articles and documents
2-oxo-1,2,3,4-tetrahydropyrimidines ethyl esters as potent β-glucuronidase inhibitors: One-pot synthesis, in vitro and in silico studies
Iqbal, Sarosh,Shaikh, Nimra N.,Khan, Khalid M.,Naz, Sehrish,Ul-Haq, Zaheer,Perveen, Shahnaz,Choudhary, Muhammad I.
, p. 818 - 830 (2018/11/30)
Background: Glucuronidation is essential for the metabolism and excretion of toxic substances. β-Glucuronidase enzyme slows down the process of glucuronidation, and thus plays an important role in the on-set of colorectal carcinoma, and many other disease
A microwave-assisted, copper-catalyzed three-component synthesis of dihydropyrimidinones under mild conditions
Pasunooti, Kalyan Kumar,Chai, Hua,Jensen, Chantel Nixon,Gorityala, Bala Kishan,Wang, Siming,Liu, Xue-Wei
supporting information; experimental part, p. 80 - 84 (2011/02/25)
The synthesis of dihydropyrimidinones via a clean multi-component Biginelli reaction under microwave irradiation is reported. The copper-catalyzed process proved to be simple, efficient, economical, and environmentally friendly.
Microwave assisted synthesis of some novel pyrimidinones/thiones
Rai, Satheesha N.,Kalluraya, Balakrishna,Lingappa,Shenoy, Shalini
experimental part, p. 1431 - 1434 (2010/03/03)
A novel scries of 1-substituted-4-aryl-5-ethoxycarbonyl-6-mcthylpyrimidine- 2-ones/thiones are prepared in the one pot condensation of appropriate aldehyde, ethylacetoacetate and substituted urea in ethanol medium under microwave irradiation. The new compounds are well characterized by IR,1H NMR, mass spectra, C.H,N-analysis and in a typical example the structure was further confirmed by X-ray crystallographic data.