42473-02-9

Basic information

• Product Name: 2-(2-oxotetrahydrofuran-3-yl)-1H-isoindole-1,3(2H)-dione
• Synonyms: 2-(2-oxotetrahydrofuran-3-yl)-1H-isoindole-1,3(2H)-dione
• CAS NO: 42473-02-9
• Molecular Formula: C₁₂H₉NO₄
• Molecular Weight: 231.21
• Mol File: 42473-02-9.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 448.7°C at 760 mmHg
• Flash Point: 225.2°C
• Appearance: /
• Density: 1.516g/cm³
• Vapor Pressure: 3.04E-08mmHg at 25°C
• Refractive Index: 1.653
• CAS DataBase Reference: 2-(2-oxotetrahydrofuran-3-yl)-1H-isoindole-1,3(2H)-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-oxotetrahydrofuran-3-yl)-1H-isoindole-1,3(2H)-dione(42473-02-9)
• EPA Substance Registry System: 2-(2-oxotetrahydrofuran-3-yl)-1H-isoindole-1,3(2H)-dione(42473-02-9)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 42473-02-9(Hazardous Substances Data)

Usage

General Description

The chemical "2-(2-oxotetrahydrofuran-3-yl)-1H-isoindole-1,3(2H)-dione" is a compound with a complex molecular structure. It contains a tetrahydrofuran ring with a carbonyl group at the second position, as well as an isoindole-1,3(2H)-dione moiety. 2-(2-oxotetrahydrofuran-3-yl)-1H-isoindole-1,3(2H)-dione has potential applications in the field of medicinal chemistry due to its unique structure, which may have biological activity. It is important to conduct further research on this compound to fully understand its properties and potential uses.

InChI:InChI=1/C12H9NO4/c14-10-7-3-1-2-4-8(7)11(15)13(10)9-5-6-17-12(9)16/h1-4,9H,5-6H2

Upstream product

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Relevant articles and documents

Search for anticonvulsant and analgesic active derivatives of dihydrofuran-2(3H)-one

A series of derivatives of dihydrofuran-2(3H)-one (γ-butyrolactone, GBL) was synthesized and tested for anticonvulsant, neurotoxic and analgesic activity. In the anticonvulsant screening 10 lactones were effective in the maximal electroshock test (MES) at the highest doses (300 and 100 mg/kg, 0.5 h, ip, mice). Statistical analysis showed correlation between the anticonvulsant activity and relative lipophilicity parameters determined by experimental and computational methods (RM0, C log P and M log P). Preliminary antinociceptive evaluation of selected derivatives revealed strong analgesic activity. The majority of the tested compounds showed high efficacy in animal models of acute pain (hot plate and writhing tests) and strong local anesthetic activity (modified tail immersion test). The obtained ED50 values were comparable with such analgesics as acetylsalicylic acid and morphine.

FACILE SYNTHESIS OF D,L-PHOSPHINOTHRICIN FROM METHYL 4-BROMO-2-PHTHALIMIDOBUTYRATE

Synthetic versatility of the title bromide is illustrated by simple preparations of D,L-phosphinothricin, D,L-2-amino-4-phosphonobutyric acid, and aminocyclopropanecarboxylic acid.