425640-16-0

Basic information

• Product Name: methyl 2-(4-bromo-1H-indol-3-yl)-2-oxoacetate
• Synonyms: methyl 2-(4-bromo-1H-indol-3-yl)-2-oxoacetate
• CAS NO: 425640-16-0
• Molecular Weight: 282.093
• Mol File: 425640-16-0.mol
• Article Data: 12

Chemical Properties

• CAS DataBase Reference: methyl 2-(4-bromo-1H-indol-3-yl)-2-oxoacetate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 2-(4-bromo-1H-indol-3-yl)-2-oxoacetate(425640-16-0)
• EPA Substance Registry System: methyl 2-(4-bromo-1H-indol-3-yl)-2-oxoacetate(425640-16-0)

Safety Data

• Hazardous Substances Data: 425640-16-0(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 52488-36-5 4-bromo-1H-indole 
• 527-31-1 hexaketocyclohexane 
• 79-37-8 oxalyl dichloride 
• 960148-53-2 2-(4-bromo-1H-indol-3-yl)-2-oxoacetyl chloride 
• 124-41-4 sodium methylate 

Downstream Products

• 202753-56-8 2-(1H-4-bromoindol-3-yl)-ethanol 
• 89245-37-4 methyl (4-bromo-1H-indole-3-yl)acetate 
• 1448699-31-7 C₁₈H₁₆BrN₃O₄S 

Relevant articles and documents

Asymmetric Synthesis of Lysergic Acid via an Intramolecular (3+2) Dipolar Cycloaddition/Ring-Expansion Sequence

An effective, potentially scalable asymmetric synthesis of lysergic acid, a core component of the ergot alkaloid family, is reported. The synthesis features the strategic combination of an intramolecular azomethine ylide cycloaddition and Cossy-Charette r

Scope of the Reactions of Indolyl- and Pyrrolyl-Tethered N-Sulfonyl-1,2,3-triazoles: Rhodium(II)-Catalyzed Synthesis of Indole- and Pyrrole-Fused Polycyclic Compounds

An efficient synthesis of tetrahydrocarboline-type products and polycyclic spiroindolines has been achieved. The transformation proceeds via rhodium(II)-catalyzed intramolecular annulations of indolyl- and pyrrolyl-tethered N-sulfonyl-1,2,3-triazoles. The reaction could be tuned toward either the formal [3 + 2] cycloaddition or the C-H functionalization reaction depending on the electronic and structural features of the substrates, leading to the production of a variety of structurally related heterocyclic compounds.

CYCLIC AMIDE DERIVATIVES AS INHIBITORS OF 11 - BETA - HYDROXYSTEROID DEHYDROGENASE AND USES THEREOF

The present invention relates to certain amide derivatives that have the ability to inhibit 11-β-hydroxysteroid dehydrogenase type 1 (11β-HSD-1) and which are therefore useful in the treatment of certain disorders that can be prevented or treated by inhibition of this enzyme. In addition the invention relates to the compounds, methods for their preparation, pharmaceutical compositions containing the compounds and the uses of these compounds in the treatment of certain disorders. It is expected that the compounds of the invention will find application in the treatment of conditions such as non-insulin dependent type 2 diabetes mellitus (NIDDM), insulin resistance, obesity, impaired fasting glucose, impaired glucose tolerance, lipid disorders such as dyslipidemia, hypertension and as well as other diseases and conditions.