425663-99-6Relevant articles and documents
Synthesis of N-[4-[1-ethyl-2-(2,4-diaminofuro[2,3-d] pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid as an antifolate1
Gangjee, Aleem,Zeng, Yibin,McGuire, John J.,Kisliuk, Roy L.
, p. 1942 - 1948 (2007/10/03)
N-[4-[1-Ethyl-2-(2,4-diaminofuro[2,3-d] pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid 3 was designed and synthesized to investigate the effect of homologation of a C9-methyl to an ethyl on dihydrofolate reductase (DHFR) inhibition and on antitumor activit