426219-53-6 Usage
General Description
TAK-700, also known as orteronel, is a chemical compound that belongs to a class of drugs called 17,20-lyase inhibitors. It works by inhibiting the activity of the enzyme 17,20-lyase, which is involved in the production of androgens such as testosterone and dihydrotestosterone. TAK-700 has been investigated as a potential treatment for hormone-sensitive cancers such as prostate cancer, where reducing androgen levels can help slow the growth of tumors. It has also been studied in the treatment of breast cancer and has shown promise in early clinical trials. However, further research is needed to determine its safety and efficacy in these and other potential applications.
Check Digit Verification of cas no
The CAS Registry Mumber 426219-53-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,2,6,2,1 and 9 respectively; the second part has 2 digits, 5 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 426219-53:
(8*4)+(7*2)+(6*6)+(5*2)+(4*1)+(3*9)+(2*5)+(1*3)=136
136 % 10 = 6
So 426219-53-6 is a valid CAS Registry Number.
426219-53-6Relevant articles and documents
1,1-Diarylalkenes as anticancer agents: Dual inhibitors of tubulin polymerization and phosphodiesterase 4
Ruchelman, Alexander L.,Man, Hon-Wah,Chen, Roger,Liu, Wei,Lu, Ling,Cedzik, Dorota,Zhang, Ling,Leisten, Jim,Collette, Alice,Narla, Rama Krishna,Raymon, Heather K.,Muller, George W.
, p. 6356 - 6374 (2011)
A series of 1,1-diarylalkene derivatives were prepared to optimize the properties of CC-5079 (1), a dual inhibitor of tubulin polymerization and phosphodiesterase 4 (PDE4). By using the 3-ethoxy-4-methoxyphenyl PDE4 pharmacophore as one of the aromatic ri