4264-35-1 Usage
Description
2-ACETYLINDOLE is a yellow crystalline solid that serves as a valuable intermediate in the synthesis of various compounds, including pharmaceutical actives, intermediates, and fine chemicals. It is an indole derivative known for its significant role in the development of matrix metalloprotease inhibitors.
Uses
Used in Pharmaceutical Industry:
2-ACETYLINDOLE is used as a key intermediate for the synthesis of pharmaceutical actives, contributing to the development of new drugs and therapies. Its role in this industry is crucial due to its ability to be incorporated into the molecular structure of various medications.
Used in Synthesis of Matrix Metalloprotease Inhibitors:
2-ACETYLINDOLE is used as a vital component in the synthesis of matrix metalloprotease inhibitors, which are essential in the treatment of various diseases and conditions. These inhibitors play a significant role in regulating the activity of matrix metalloproteases, a group of enzymes involved in the breakdown of extracellular matrix proteins, and have potential applications in cancer treatment, arthritis, and other conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 4264-35-1 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,2,6 and 4 respectively; the second part has 2 digits, 3 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 4264-35:
(6*4)+(5*2)+(4*6)+(3*4)+(2*3)+(1*5)=81
81 % 10 = 1
So 4264-35-1 is a valid CAS Registry Number.
InChI:InChI=1/C10H9NO/c1-7(12)10-6-8-4-2-3-5-9(8)11-10/h2-6,11H,1H3
4264-35-1Relevant articles and documents
Imidazolium Triflate Ionic Liquid Improves the Activity of ZnCl2 in the Synthesis of Pyrroles and Ketones
Nguyen, Hai Truong,Ngo, Dung Kim Thi,Chau, Khiem Duy Nguyen,Tran, Phuong Hoang
, p. 157 - 165 (2021/03/16)
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Iodine-mediated intramolecular amination of ketones: The synthesis of 2-acylindoles and 2-acylindolines by tuning N-protecting groups
Gao, Wen-Chao,Jiang, Shan,Wang, Ruo-Lin,Zhang, Chi
supporting information, p. 4890 - 4892 (2013/07/05)
A general method for constructing both 2-acylindoles and 2-acylindolines via I2-mediated intramolecular C-N bond formation is presented, and the selective formation of either 2-acylindoles or 2-acylindolines just depends on the nitrogen protecting groups used in the same substrate skeletons. The Royal Society of Chemistry.
THE FORMATION OF SUBSTITUTED INDOLES BY ACID CATALYZED REARRANGEMENTS OF 4-ISOXAZOLINES
Liguori, Angelo,Ottana', Rosaria,Romeo, Giovanni,Sindona, Giovanni,Uccella, Nicola
, p. 1365 - 1376 (2007/10/02)
Thermal rearrangements of 4-isoxazolines from C,N-diphenylnitrone and substituted alkynes have been directed towards the formation of substituted indoles.Detection and isolation of the intermediates of the process elucidate the reaction pathway.The appropriate choice of substituents and experimental conditions has allowed the control of the single steps involved in the total process.