426844-51-1

Basic information

• Product Name: 4,4-DIFLUORO-L-PROLINAMIDE HYDROCHLORIDE
• Synonyms: 4,4-DIFLUORO-L-PROLINAMIDE HYDROCHLORIDE;4,4-Difluoro-l-prolinaMide, HCl;(S)-4,4-difluoropyrrolidine-2-carboxamide hydrochloride;-4,4-Difluoropyrrolidine-2-carboxamide hydrochloride
• CAS NO: 426844-51-1
• Molecular Formula: C5H9ClF2N2O
• Molecular Weight: 186.59
• Mol File: 426844-51-1.mol
• Article Data: 0

Chemical Properties

• Melting Point: 222°C
• Boiling Point: 327.5ºC at 760 mmHg
• Flash Point: 151.9 ºC
• Appearance: /
• Density: g/cm³
• Vapor Pressure: 0.000145mmHg at 25°C
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility: DMSO (Slightly), Methanol (Slightly)
• CAS DataBase Reference: 4,4-DIFLUORO-L-PROLINAMIDE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4,4-DIFLUORO-L-PROLINAMIDE HYDROCHLORIDE(426844-51-1)
• EPA Substance Registry System: 4,4-DIFLUORO-L-PROLINAMIDE HYDROCHLORIDE(426844-51-1)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26
• WGK Germany: 3
• Hazardous Substances Data: 426844-51-1(Hazardous Substances Data)

Usage

Description

4,4-Difluoro-L-prolinamide hydrochloride is an organic compound that serves as a crucial building block in the synthesis of various pharmaceutical compounds, particularly those targeting DPP-IV (Dipeptidyl peptidase-IV) inhibitors. It is characterized by its unique chemical structure, which includes a fluorinated prolinamide moiety and a hydrochloride salt form. 4,4-DIFLUORO-L-PROLINAMIDE HYDROCHLORIDE plays a significant role in the development of novel therapeutic agents for treating type 2 diabetes and other related metabolic disorders.

Uses

Used in Pharmaceutical Industry:
4,4-Difluoro-L-prolinamide hydrochloride is used as a key building block for the synthesis of cyanopyrrolidine-based DPP-IV inhibitors. These inhibitors are essential in the development of drugs that help regulate blood glucose levels in patients with type 2 diabetes. By targeting DPP-IV, these inhibitors can slow down the degradation of incretin hormones, which in turn stimulates insulin secretion and reduces glucose production in the liver.
Additionally, 4,4-Difluoro-L-prolinamide hydrochloride can be utilized in the development of other therapeutic agents that target different enzymes or receptors involved in various diseases. Its unique chemical structure allows for the creation of novel compounds with potential applications in treating a wide range of medical conditions.

InChI:InChI=1/C5H8F2N2O.ClH/c6-5(7)1-3(4(8)10)9-2-5;/h3,9H,1-2H2,(H2,8,10);1H/t3-;/m0./s1

Downstream Products

• 1448440-48-9 (S)-tert-butyl 2-(2-carbamoyl-4,4-difluoropyrrolidin-1-yl)-2-oxoethylcarbamate