427-63-4

Basic information

• Product Name: GEODIN
• Synonyms: SPIRO[BENZOFURAN-2(3H),1'-[2,5]CYCLOHEXADIENE]-2'-CARBOXYLIC ACID, 5,7-DICHLORO-4-HYDROXY-6'-METHOXY-6-METHYL-3,4'-DIOXO-, METHYL ESTER;GEODIN;(+)-ESTIN;Estin, (+)-5,7-dichloro-4-hydroxy-6-methoxy-6-methyl-3,4-dioxo-spiro[benzofuran-2(3H),1-[2,5]cyclohexadiene]-2-carboxylic acid methyl ester;(1R)-3',4-Dioxo-4'-hydroxy-5',7'-dichloro-6-methoxy-6'-methylspiro[2,5-cyclohexadiene-1,2'(3'H)-benzofuran]-2-carboxylic acid methyl ester;(1R)-3',4-Dioxo-4'-hydroxy-5',7'-dichloro-6'-methyl-6-methoxyspiro[2,5-cyclohexadiene-1,2'(3'H)-benzofuran]-2-carboxylic acid methyl ester;(R)-5,7-Dichloro-4-hydroxy-6'-methoxy-6-methyl-3,4'-dioxospiro[benzofuran-2(3H),1'-[2,5]cyclohexadiene]-2'-carboxylic acid methyl ester;d-Geodin
• CAS NO: 427-63-4
• Molecular Formula: C17H12Cl2O7
• Molecular Weight: 399.18
• Mol File: 427-63-4.mol
• Article Data: 1

Chemical Properties

• Melting Point: 235℃
• Boiling Point: 652.1 °C at 760 mmHg
• Flash Point: 348.2 °C
• Appearance: /
• Density: 1.61 g/cm³
• CAS DataBase Reference: GEODIN(CAS DataBase Reference)
• NIST Chemistry Reference: GEODIN(427-63-4)
• EPA Substance Registry System: GEODIN(427-63-4)

Safety Data

• Hazardous Substances Data: 427-63-4(Hazardous Substances Data)

Usage

Description

GEODIN, also known as (+)-Geodin, is a fungal metabolite that has been found to possess various biological activities. It is known for its ability to increase the fibrinolytic activity of bovine aortic endothelial cells (BAECs) at concentrations ranging from 50 to 150 μM. Additionally, GEODIN has been shown to enhance 2-deoxyglucose uptake by rat adipocytes when used at concentrations between 1-100 μg/ml. Furthermore, GEODIN acts as an inhibitor of plasminogen activator inhibitor (PAI-1), making it a potential candidate for therapeutic applications.

Uses

Used in Pharmaceutical Applications:
GEODIN is used as a therapeutic agent for promoting fibrinolysis and inhibiting plasminogen activator inhibitor (PAI-1). This application is particularly relevant in the treatment of conditions related to impaired fibrinolytic activity, such as thrombotic disorders and cardiovascular diseases.
Used in Research Applications:
GEODIN is used as a research tool for studying the mechanisms underlying fibrinolysis and the role of PAI-1 in various pathological processes. Its ability to increase 2-deoxyglucose uptake by rat adipocytes also makes it a valuable compound for investigating glucose metabolism and its regulation in cellular systems.
Used in Drug Development:
GEODIN's inhibitory effect on PAI-1 and its potential to enhance fibrinolytic activity make it a promising candidate for the development of new drugs targeting thrombotic and cardiovascular disorders. Further research and development efforts may lead to the creation of novel therapeutic agents based on GEODIN's unique properties.

Upstream product

• 2151-16-8 methyl 2-(3,5-dichloro-2,6-dihydroxy-4-methylbenzoyl)-5-hydroxy-3-methoxybenzoate 

Downstream Products

• 102173-59-1 methyl 2,4-dichloroasterrate 

Relevant articles and documents

Purification and characterization of dihydrogeodin oxidase from a fungal strain of Aspergillus terreus producing (+)-geodin

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