4278-08-4

Basic information

• Product Name: 2-(4-FLUORO-PHENYL)-1H-IMIDAZOLE
• Synonyms: 2-(4-FLUORO-PHENYL)-1H-IMIDAZOLE
• CAS NO: 4278-08-4
• Molecular Formula: C₉H₇FN₂
• Molecular Weight: 162.16
• Mol File: 4278-08-4.mol
• Article Data: 5

Chemical Properties

• Melting Point: 196-198 °C
• Boiling Point: 332.2±25.0 °C(Predicted)
• Appearance: /
• Density: 1.242±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 12.90±0.10(Predicted)
• CAS DataBase Reference: 2-(4-FLUORO-PHENYL)-1H-IMIDAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-FLUORO-PHENYL)-1H-IMIDAZOLE(4278-08-4)
• EPA Substance Registry System: 2-(4-FLUORO-PHENYL)-1H-IMIDAZOLE(4278-08-4)

Safety Data

• Statements: 41
• Safety Statements: 26-39
• Hazardous Substances Data: 4278-08-4(Hazardous Substances Data)

Usage

General Description

2-(4-Fluoro-phenyl)-1H-imidazole is a chemical compound that belongs to the group of imidazole derivatives, characterized by a five-membered ring structure containing two nitrogen atoms. It is distinct due to the presence of a fluorine atom attached to the phenyl ring. The presence of fluorine can have a significant impact on the compound’s reactivity, as well as its properties and biological activity. Imidazole derivatives are widely acknowledged in the field of medicinal chemistry, and feature prominently in numerous pharmaceutical drugs. However, specific information about 2-(4-Fluoro-phenyl)-1H-imidazole's particular uses or properties may not be directly available, and would likely depend on further chemical modification or application in specific research contexts.

Upstream product

• 165901-26-8 2-(4-fluorophenyl)-4,5-dihydro-1H-imidazole 
• 459-57-4 4-fluorobenzaldehyde 

Downstream Products

• 72542-80-4 5-(4-fluoro-phenyl)-[1,2,4]oxadiazole-3-carboxylic acid 
• 1253697-41-4 2-(4-fluorophenyl)-1-(phenylsulfonyl)-1H-imidazole 
• 1313519-31-1 C₂₁H₂₁FN₆O₅ 
• 1313519-32-2 C₂₀H₁₉FN₆O₂ 
• 1313572-42-7 C₂₄H₂₀F₂N₆O 
• 1313519-44-6 4-(7-ethyl-2-(2-(4-fluorophenyl)-1H-imidazol-1-yl)-5-methyl-6-oxo-6,7-dihydropteridin-8(5H)-yl)benzonitrile 
• 1313519-40-2 (R)-7-ethyl-2-(2-(4-fluorophenyl)-1H-imidazol-1-yl)-5-methyl-8-(1H-pyrazol-4-yl)-7,8-dihydropteridin-6(5H)-one 
• 1313519-45-7 7-ethyl-2-(2-(4-fluorophenyl)-1H-imidazol-1-yl)-5-methyl-8-(1H-pyrazol-3-yl)-7,8-dihydropteridin-6(5H)-one 
• 1313519-64-0 (R)-7-ethyl-2-(2-(4-fluorophenyl)-1H-imidazol-1-yl)-5-methyl-8-(1-methyl-1H-pyrazol-4-yl)-7,8-dihydropteridin-6(5H)-one 
• 1313519-83-3 C₂₂H₂₁FN₈O 
• 1431659-52-7 C₂₂H₂₁FN₈O 
• 1313522-44-9 C₂₁H₁₇F₇N₆O 
• 1313523-55-5 C₂₂H₂₂F₄N₆O 
• 1313523-58-8 C₂₂H₂₃FN₆O 

Relevant articles and documents

New Insights into the Role of Imidazolium-Based Promoters for the Electroreduction of CO2 on a Silver Electrode

The electrochemical reduction of CO2 to CO is a reaction of central importance for sustainable energy conversion and storage. Herein, structure-activity relationships of a series of imidazolium-based cocatalysts for this reaction are described,

COMPOUNDS FOR TREATMENT OF CANCER

The present invention relates to novel compounds having anti-cancer activity, methods of making these compounds, and their use for treating cancer and drug-resistant tumors, e.g. melanoma, metastatic melanoma, drug resistant melanoma, prostate cancer and drug resistant prostate cancer.

1H-IMIDAZOLE PREPARATION VIA PERMANGANATE DEHYDROGENATION OF 2-IMIDAZOLINES

Permanganate and manganate ions were evaluated as dehydrogenating agents in the conversion of 2-substituted 2-imidazolines into the corresponding 2-substituted imidazoles.It was found that permanganate ion in dry dioxane efficiently performs this transformation rendering this method competitive with related procedures.