427878-70-4

Basic information

• Product Name: Pyrrolo[2,1-f][1,2,4]triazine-6-carboxylic acid, 1,4-dihydro-5-methyl-4-oxo-, ethyl ester
• Synonyms: Pyrrolo[2,1-f][1,2,4]triazine-6-carboxylic acid, 1,4-dihydro-5-methyl-4-oxo-, ethyl ester;Ethyl 5-methyl-4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazine-6-carboxylate;5-Methyl-4-oxo-3,4-dihydro-pyrrolo[2,1-f][1,2,4]triazine-6-carboxylic acid ethyl ester;Ethyl 4-hydroxy-5-methylpyrrolo[1,2-f][1,2,4]triazine-6-carboxylate;ethyl 4-hydroxy-5-Methyl -4a,5-dihydro pyrrolo[1,2-f][1,2,4]triazine-6-carboxylate;Ethyl 4-hydroxy-5-Methylp...;ethyl 5-Methyl-4-oxo-3,4-dihydropyrrolo[2,1-f][1,2,4]triazine-6-carboxylate;Ethyl 4-hydroxy-5-Methylpyrrolo[2,1-f][1,2,4]triazine-6-carboxylate
• CAS NO: 427878-70-4
• Molecular Formula: C₁₀H₁₁N₃O₃
• Molecular Weight: 221.21264
• EINECS: -0
• Mol File: 427878-70-4.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 400.913 °C at 760 mmHg
• Flash Point: 196.265 °C
• Appearance: Yellow/Powder
• Density: 1.417 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.641
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: Pyrrolo[2,1-f][1,2,4]triazine-6-carboxylic acid, 1,4-dihydro-5-methyl-4-oxo-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Pyrrolo[2,1-f][1,2,4]triazine-6-carboxylic acid, 1,4-dihydro-5-methyl-4-oxo-, ethyl ester(427878-70-4)
• EPA Substance Registry System: Pyrrolo[2,1-f][1,2,4]triazine-6-carboxylic acid, 1,4-dihydro-5-methyl-4-oxo-, ethyl ester(427878-70-4)

Safety Data

• Hazardous Substances Data: 427878-70-4(Hazardous Substances Data)

Usage

General Description

Pyrrolo[2,1-f][1,2,4]triazine-6-carboxylic acid, 1,4-dihydro-5-methyl-4-oxo-, ethyl ester, also known as PTCE, is a chemical compound with potential pharmacological activities. PTCE is an ethyl ester derivative of pyrrolo[2,1-f][1,2,4]triazine-6-carboxylic acid, 1,4-dihydro-5-methyl-4-oxo-, which is a heterocyclic compound. Pyrrolo[2,1-f][1,2,4]triazine-6-carboxylic acid, 1,4-dihydro-5-methyl-4-oxo-, ethyl ester has been studied for its potential applications in drug development, particularly in cancer and infectious diseases. PTCE has shown inhibitory effects on certain enzymes and has demonstrated potential as an antiviral and antitumor agent. Further research is needed to fully understand the pharmacological properties and potential therapeutic applications of PTCE.

InChI:InChI=1/C10H11N3O3/c1-3-16-10(15)7-4-13-8(6(7)2)9(14)11-5-12-13/h4-5H,3H2,1-2H3,(H,11,12,14)

Upstream product

• 77287-34-4 formamide 
• 427878-69-1 1-amino-3-methyl-1H-pyrrole-2,4-dicarboxylic acid diethyl ester 
• 5448-16-8 3-methyl-1H-pyrrole-2,4-dicarboxylic acid diethyl ester 
• 134653-70-6 ethyl 2-[(dimethylamino)methylene]-3-oxobutanoate 
• 141-97-9 ethyl acetoacetate 
• 1400934-08-8 diethyl 1-(4-bromobenzamido)-3-methyl-1H-pyrrole-2,4-dicarboxylate 
• 1400934-13-5 diethyl 1-(4-methoxybenzamido)-3-methyl-1H-pyrrole-2,4-dicarboxylate 
• 1400934-06-6 diethyl 1-(3-chlorobenzamido)-3-methyl-1H-pyrrole-2,4-dicarboxylate 
• 1400934-02-2 diethyl 1-(4-nitrobenzamido)-3-methyl-1H-pyrrole-2,4-dicarboxylate 
• 1400934-04-4 diethyl 1-(4-fluorobenzamido)-3-methyl-1H-pyrrole-2,4-dicarboxylate 
• 1400934-11-3 diethyl 1-(4-chlorobenzamido)-3-methyl-1H-pyrrole-2,4-dicarboxylate 

Downstream Products

• 427878-41-9 4-chloro-5-methyl-pyrrolo[2,1-f][1,2,4]triazine-6-carboxylic acid ethyl ester 
• 621685-54-9 C₈H₉N₃O₂ 
• 623152-50-1 C₂₄H₂₁N₅O₄ 
• 623152-49-8 C₃₂H₂₉FN₆O₃ 
• 621685-42-5 C₂₄H₂₃N₅O₃ 
• 621685-41-4 C₂₅H₂₅N₅O₃ 
• 621685-48-1 C₂₄H₂₃N₅O₂ 
• 621685-51-6 C₂₄H₂₃N₅O₃ 
• 621685-40-3 C₂₄H₂₃N₅O₃ 
• 621685-50-5 C₂₄H₂₃N₅O₃ 
• 621685-52-7 C₂₃H₂₀FN₅O₂ 
• 621685-49-2 C₂₃H₂₀FN₅O₂ 
• 621685-53-8 C₂₄H₂₁N₅O₄ 
• 621685-47-0 C₂₃H₂₂N₆O₂ 

Relevant articles and documents

TYROSINE KINASE INHIBITOR AND PHARMACEUTICAL COMPOSITION COMPRISING SAME

The present invention relates to a tyrosine kinase inhibitor and a pharmaceutical composition comprising same. The tyrosine kinase inhibitor of the present invention has the structures as shown in the following formula (I) or (II):

Development of a practical synthesis of a functionalized pyrrolo[2,1-f][1,2,4]triazine nucleus

Functionalized pyrrolotriazine 1b is a key heterocyclic building block in the synthesis of BMS-690514, a potent anticancer agent. Described herein are our development activities that led to the efficient preparation of 1b on a large scale. The key transformations include a selective C-alkylation of an oxalacetate salt with a hydrazonyl bromide to form a 2-hydrazonoethyl-3- oxosuccinate, followed by cyclodehydration to an aminopyrrole. Subsequent deprotection and condensation with formamidine afforded the pyrrolotriazine scaffold. Further elaboration of this core provided the desired pyrrolotriazinyl amine.

Synthesis and SAR of new pyrrolo[2,1-f][1,2,4]triazines as potent p38α MAP kinase inhibitors

A novel series of compounds based on the pyrrolo[2,1-f][1,2,4]triazine ring system have been identified as potent p38α MAP kinase inhibitors. The synthesis, structure-activity relationships (SAR), and in vivo activity of selected analogs from this class o