427900-17-2

Basic information

• Product Name: 6-BROMO-N-(PHENYLMETHYL)-2-PYRIDINAMINE
• Synonyms: 2-PYRIDINAMINE, 6-BROMO-N-(PHENYLMETHYL)-;6-BROMO-N-(PHENYLMETHYL)-2-PYRIDINAMINE;2-Benzylamino-6-bromopyridine;N-benzyl-6-broMopyridin-2-aMine
• CAS NO: 427900-17-2
• Molecular Formula: C₁₂H₁₁BrN₂
• Molecular Weight: 263.137
• Mol File: 427900-17-2.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 6-BROMO-N-(PHENYLMETHYL)-2-PYRIDINAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-BROMO-N-(PHENYLMETHYL)-2-PYRIDINAMINE(427900-17-2)
• EPA Substance Registry System: 6-BROMO-N-(PHENYLMETHYL)-2-PYRIDINAMINE(427900-17-2)

Safety Data

• Hazardous Substances Data: 427900-17-2(Hazardous Substances Data)

Usage

General Description

6-Bromo-N-(phenylmethyl)-2-pyridinamine is a chemical compound with the molecular formula C12H11BrN2. It is a pyridine derivative with a bromine atom and a phenylmethyl group attached to the nitrogen atom. 6-BROMO-N-(PHENYLMETHYL)-2-PYRIDINAMINE has potential applications in the field of pharmaceuticals and organic synthesis, where it can be used as an intermediate for the synthesis of various biologically active molecules. Its unique structure and reactivity make it a valuable building block for the creation of new drugs and other important chemical compounds. Overall, 6-Bromo-N-(phenylmethyl)-2-pyridinamine is a versatile compound with promising potential in the field of chemical research and drug development.

Upstream product

• 626-05-1 2,6-Dibromopyridine 
• 100-46-9 benzylamine 
• 19798-81-3 2-Amino-6-bromopyridine 
• 100-51-6 benzyl alcohol 

Downstream Products

• 427900-22-9 N-(6'-bromo-2'-pyridyl)-N'-(6''-benzylamino-2''-pyridyl)-2,6-diaminopyridine 
• 1589587-97-2 C₁₆H₁₂BrClN₄ 
• 1589588-19-1 C₂₃H₂₀BrN₅ 
• 1589588-48-6 C₆₉H₅₇N₁₅ 

Relevant articles and documents

Rational Optimization of Lewis-Acid Catalysts for Direct Alcohol Amination, Part 2 – Titanium Triflimide as New Active Catalyst

The reactivity of a new titanium triflimide salt (see Part 1) was investigated for the direct amination of alcohols. The combination of this new Lewis acid with pyridine-based ligands allowed a significant increase of activity. The scope of the reaction was increased compared to other Lewis-acid-based protocols. Finally, mechanistic insights based on EPR spectroscopy and DFT calculations are provided.

Synthesis, structure, and fullerene-complexing property of azacalix[6]aromatics

Synthesis, structure, and fullerene-binding property of azacalix[6]aromatics were systematically studied. By means of [3 + 3] and [2 + 2 + 2] fragment coupling protocols, a number of azacalix[6]aromatics containing different combinations of benzene, pyridine, and pyrimidine rings and various substituents on the bridging nitrogen atoms were synthesized conveniently in moderate to good yields. The resulting macrocycles adopt in the solid state symmetric and heavily distorted 1,3,5-alternate conformations depending on the aromatic building units, whereas, in solution, they exist as a mixture of conformers that undergo rapid interchanges relative to the NMR time scale. All macrocycles were able to form 1:1 complexes with C60 and C 70 in toluene with the association constants up to 7.28 × 104 M-1. In the crystalline state, azacalix[6]aromatics form complexes with C60 and C70 with 2:1, 1:1, and 1:2 stoichiometric ratios between host and guest. Azacalix[6]aromatics interact with fullerene by forming mainly the sandwich structure in which C60 or C70 is sandwiched by two macrocycles. X-ray molecular structures revealed that multiple π-π and CH-π interactions between concave azacalix[6]aromatics and convex fullerenes C60 and C70 contribute a joint driving force to the formation of host-guest complexes.

Palladium-catalysed amination of halopyridines on a KF-alumina surface

Palladium-catalysed C-N hetero cross-coupling reactions between bromopyridines and amines (both primary and secondary) can be efficiently performed on a KF-alumina (basic) surface, thus negating the use of strong bases such as sodium tert-butoxide. The reaction conditions are optimised with reference to catalytic systems, solvents and the surface.