42794-76-3

Basic information

• Product Name: MIDODRINE
• Synonyms: MIDODRINE;Acetamide, 2-amino-N-[2-(2,5-dimethoxyphenyl)-2-hydroxyethyl]- (9CI);2-Amino-N-(2,5-dimethoxy-β-hydroxyphenethyl)acetamide
• CAS NO: 42794-76-3
• Molecular Formula: C₁₂H₁₈N₂O₄
• Molecular Weight: 254.28
• EINECS: 255-945-3
• Mol File: 42794-76-3.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 529.9±50.0 °C(Predicted)
• Appearance: /
• Density: 1.204±0.06 g/cm3(Predicted)
• PKA: 13.47±0.20(Predicted)
• CAS DataBase Reference: MIDODRINE(CAS DataBase Reference)
• NIST Chemistry Reference: MIDODRINE(42794-76-3)
• EPA Substance Registry System: MIDODRINE(42794-76-3)

Safety Data

• Hazardous Substances Data: 42794-76-3(Hazardous Substances Data)

Usage

Description

MIDODRINE is an aromatic ether that is 1,4-dimethoxybenzene, substituted at position 2 by a 2-(glycylamino)-1-hydroxyethyl group. It is a direct-acting sympathomimetic with selective alpha-adrenergic agonist activity. MIDODRINE is primarily used as a peripheral vasoconstrictor in the treatment of certain hypotensive states. Its main active component is its major metabolite, deglymidodrine.

Uses

Used in Pharmaceutical Industry:
MIDODRINE is used as an antihypotensive agent for the treatment of certain hypotensive states. It functions as a peripheral vasoconstrictor, helping to increase blood pressure and improve blood flow in individuals suffering from low blood pressure conditions.
Used in Medical Treatment:
MIDODRINE is used as a therapeutic agent in the management of orthostatic hypotension, a condition where blood pressure drops significantly upon standing. It helps to alleviate symptoms such as dizziness, lightheadedness, and fatigue associated with this condition.
Used in Clinical Settings:
MIDODRINE is utilized in clinical settings to treat patients with symptomatic neurogenic orthostatic hypotension, a condition that results from the dysfunction of the autonomic nervous system. It helps to improve the patient's quality of life by reducing the severity of symptoms and enhancing their ability to perform daily activities.

InChI:InChI=1/C12H18N2O4/c1-17-8-3-4-11(18-2)9(5-8)10(15)7-14-12(16)6-13/h3-5,10,15H,6-7,13H2,1-2H3,(H,14,16)

Upstream product

• 176851-43-7 N-(2-(2,5-Dimethoxyphenyl)-2-hydroxyethyl)-2-((1,1-dimethylethoxy)carbonylamino)essigsaeureamid 
• 60407-53-6 1-(2',5'-dimethoxyphenyl)-2-aminoethanol hydrochloride 

Downstream Products

• 133163-28-7 midodrine hydrochloride 

Relevant articles and documents

Organobase-catalyzed amidation of esters with amino alcohols

A base-mediated procedure for the amidation of unactivated esters with amino alcohols is reported. Optimization and exemplification of the catalytic process are described, furnishing products in 40-100% isolated yield.

A process for the preparation of midodrine

The invention provides a process for the preparation of 2-amino-N-[2-(2,5-dimethoxyphenyl)-2-hydroxyethyl]acetamide of the formula 1 by hydrogenolysis of substituted 2-dibenzylamino-N-[2-(2',5'-dimethoxyphenyl)-2-hydroxy-ethyl]acetamide having the formula (5), wherein Ar and Ar' are aryl groups.