42908-77-0

Basic information

• Product Name: 2-TRIFLUOROMETHOXY TOLUENE
• Synonyms: 2-TRIFLUOROMETHOXY TOLUENE;1-Methyl-2-(trifluoroMethoxy)benzene
• CAS NO: 42908-77-0
• Molecular Formula: C₈H₇F₃O
• Molecular Weight: 176.14
• Mol File: 42908-77-0.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 127.5 °C at 760 mmHg
• Flash Point: 36.6 °C
• Appearance: /
• Density: 1.206 g/cm³
• Vapor Pressure: 13.5mmHg at 25°C
• Refractive Index: 1.436
• CAS DataBase Reference: 2-TRIFLUOROMETHOXY TOLUENE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-TRIFLUOROMETHOXY TOLUENE(42908-77-0)
• EPA Substance Registry System: 2-TRIFLUOROMETHOXY TOLUENE(42908-77-0)

Safety Data

• Hazard Codes: T
• Hazardous Substances Data: 42908-77-0(Hazardous Substances Data)

Usage

General Description

2-Trifluoromethoxy toluene, also known as 1-(Trifluoromethoxy)-2-methylbenzene, is a colorless liquid with the chemical formula C8H7F3O. It is commonly used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. This chemical is a highly flammable liquid and should be handled with care. It is also harmful if swallowed or inhaled, and can cause irritation to the skin and eyes. 2-Trifluoromethoxy toluene is primarily used in research and development laboratories and chemical manufacturing facilities.

InChI:InChI=1/C8H7F3O/c1-6-4-2-3-5-7(6)12-8(9,10)11/h2-5H,1H3

Upstream product

• 1736-10-3 2-(trifluoroacetoxy)toluene 
• 456-55-3 1-trifluoromethoxybenzene 
• 74-88-4 methyl iodide 
• 108-88-3 toluene 

Downstream Products

• 7450-03-5 (2-methylphenyl)trimethylsilane 

Relevant articles and documents

Photocatalytic trifluoromethoxylation of arenes and heteroarenes in continuous-flow

The first example of photocatalytic trifluoromethoxylation of arenes and heteroarenes under continuous-flow conditions is described. Application of continuous-flow microreactor technology allowed to reduce the residence time up to 16 times in comparison t

Redox-Active Reagents for Photocatalytic Generation of the OCF3 Radical and (Hetero)Aryl C?H Trifluoromethoxylation

The trifluoromethoxy (OCF3) radical is of great importance in organic chemistry. Yet, the catalytic and selective generation of this radical at room temperature and pressure remains a longstanding challenge. Herein, the design and development of a redox-active cationic reagent (1) that enables the formation of the OCF3 radical in a controllable, selective, and catalytic fashion under visible-light photocatalytic conditions is reported. More importantly, the reagent allows catalytic, intermolecular C?H trifluoromethoxylation of a broad array of (hetero)arenes and biorelevant compounds. Experimental and computational studies suggest single electron transfer (SET) from excited photoredox catalysts to 1 resulting in exclusive liberation of the OCF3 radical. Addition of this radical to (hetero)arenes gives trifluoromethoxylated cyclohexadienyl radicals that are oxidized and deprotonated to afford the products of trifluoromethoxylation.

Selective aromatic carbon-oxygen bond cleavage of trifluoromethoxyarenes: a trifluoromethoxy group as a convertible directing group

An efficient method for selective activation of aromatic C-O bonds in trifluoromethoxyarenes is developed. Upon treatment with a metallic sodium/chlorotrimethylsilane system, trifluoromethoxyarenes undergo reductive dealkoxylation to provide the corresponding arylsilanes. Also the synthetic applications of the present reactions combined with ortho-metallation are described.