4298-52-6 Usage
Description
2-Ethynylthiophene is an organic compound characterized by its clear yellow liquid appearance. It is a derivative of thiophene, a heterocyclic compound with a sulfur atom in the ring, and features an ethynyl group attached to the second carbon position. This unique structure endows 2-Ethynylthiophene with specific chemical properties that make it suitable for various applications in different industries.
Uses
Used in Pharmaceutical Industry:
2-Ethynylthiophene is used as a key intermediate in the synthesis of triazole derivatives, which serve as Hsp90 inhibitors and anti-cancer metastasis drugs. Hsp90, or heat shock protein 90, is a protein that plays a crucial role in the stabilization and proper folding of other proteins. Inhibiting Hsp90 can disrupt the function of proteins involved in cancer cell survival and proliferation, making it a promising target for cancer therapy.
The anti-cancer metastasis properties of 2-Ethynylthiophene-based drugs are attributed to their ability to interfere with the process of cancer cell migration and invasion, which are critical steps in the metastasis of cancer. By targeting these processes, 2-Ethynylthiophene-derived drugs can potentially limit the spread of cancer to other parts of the body, improving patient outcomes.
Synthesis Reference(s)
The Journal of Organic Chemistry, 41, p. 1487, 1976 DOI: 10.1021/jo00871a001Synthesis, p. 589, 1996 DOI: 10.1055/s-1996-4265
Check Digit Verification of cas no
The CAS Registry Mumber 4298-52-6 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,2,9 and 8 respectively; the second part has 2 digits, 5 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 4298-52:
(6*4)+(5*2)+(4*9)+(3*8)+(2*5)+(1*2)=106
106 % 10 = 6
So 4298-52-6 is a valid CAS Registry Number.
InChI:InChI=1/C6H4S/c1-2-6-4-3-5-7-6/h1,3-5H
4298-52-6Relevant articles and documents
Reactions of Thiophene and Alkylthiophenes in Glow Discharge
Skramstad, Jan,Chaudhry, Mohammed Shoaib,Garvang, Arne
, p. 509 - 512 (2007/10/02)
The glow discharge reaction of thiophene is shown to produce thioketene and carbon monosulfide along with other gaseous products.The dominant liquid product is ethynylthiophene.Methylthiophenes and especially dimethylthiophenes produce benzene as one of the major liquid products.