42982-49-0Relevant articles and documents
Environmentally-friendly synthesis method of ulipristal acetate intermediate and ulipristal acetate
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Paragraph 0027; 0036-0041, (2020/07/14)
The invention provides a method for environmentally-friendly synthesis of an ulipristal acetate intermediate and ulipristal acetate. According to the invention, a compound 2 is used as a starting rawmaterial, and reacts with acetylene in a solvent to form an alkynyl alcohol compound intermediate 3, a hydration reaction is performed with water under the catalysis of an ionic liquid and CO2 to obtain an intermediate 4, the intermediate 4 is subjected to carbonyl protection to obtain an intermediate 5, and the intermediate 5 is subjected to double bond epoxidation, a Grignard reaction, decarbonylation protection and acetylation to obtain the high-purity ulipristal acetate. The method is environment-friendly, convenient in steps, mild in conditions, low in cost, easy to amplify and suitable for industrial production, and the solvent can be recycled.
20-ketofatty -11β-arylpropionic agonists or antagonists and having its deriv. nonsteroid antiandrogenic characteristics
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, (2019/05/08)
The invention is directed to a novel class of steroids which exhibit potent antiprogestational activity.
17β-acyl-17α-propynyl-11β-(cyclic amino) aryl steroids and their derivatives having antagonist hormonal properties
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Page/Page column 20, (2008/06/13)
The invention is directed to a novel class of 17β-acyl-17α-propynyl steroids which exhibit potent antiprogestational activity.