43021-26-7 Usage
Description
ECGONIDINE METHYL ESTER MESYLATE, also known as methylecgonidine, is a pyrolysis product formed when crack cocaine is smoked. It is a metabolite of Cocaine (COC) and is characterized by its clear, colorless oil appearance. Due to its unique formation, it serves as a specific biomarker for the detection of crack cocaine use, distinguishing it from the use of powder cocaine, which does not produce methylecgonidine as a metabolite. It is considered a controlled substance in some countries.
Uses
Used in Drug Testing:
ECGONIDINE METHYL ESTER MESYLATE is used as a biomarker for the detection of crack cocaine use. It is particularly useful in distinguishing between the use of crack cocaine and powder cocaine, as the latter does not form methylecgonidine as a metabolite.
Used in Forensic Science:
In the field of forensic science, ECGONIDINE METHYL ESTER MESYLATE is used as a chemical marker to identify and confirm the presence of crack cocaine in cases involving drug-related crimes or incidents.
Used in Research and Development:
ECGONIDINE METHYL ESTER MESYLATE is utilized in research and development for the study of cocaine metabolism and the effects of crack cocaine use on human health. This information can contribute to the development of new testing methods, treatment strategies, and prevention programs.
Used in Regulatory Compliance:
As a controlled substance in some countries, ECGONIDINE METHYL ESTER MESYLATE is used in regulatory compliance efforts to monitor and control the distribution, sale, and use of crack cocaine and its related substances.
Used in Public Health Initiatives:
Public health organizations may use ECGONIDINE METHYL ESTER MESYLATE as a tool to raise awareness about the risks associated with crack cocaine use and to support initiatives aimed at reducing drug abuse and its associated health and social consequences.
Check Digit Verification of cas no
The CAS Registry Mumber 43021-26-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 4,3,0,2 and 1 respectively; the second part has 2 digits, 2 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 43021-26:
(7*4)+(6*3)+(5*0)+(4*2)+(3*1)+(2*2)+(1*6)=67
67 % 10 = 7
So 43021-26-7 is a valid CAS Registry Number.
InChI:InChI=1/C10H15NO2/c1-11-7-3-5-8(10(12)13-2)9(11)6-4-7/h5,7,9H,3-4,6H2,1-2H3/t7-,9-/m1/s1
43021-26-7Relevant articles and documents
METHOD FOR THE PREPARATION OF N-MONOFLUOROALKYL TROPANES AND THEIR USE
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Page/Page column 15, (2021/07/31)
The present invention relates to a method for the preparation of an N-monofluoroalkyl tropane, a method for the preparation of a trialkyltin tropane, a method for the preparation of an iodinated and/or radioiodinated tropane and the use of the N-monofluoroalkyl tropane as a precursor in the method for the preparation of the trialkyltin tropane and/or the iodinated and/or radioiodinated tropane.
Synthesis of 3-arylecgonine analogues as inhibitors of cocaine binding and dopamine uptake
Kline Jr.,Wright,Fox,Eldefrawi
, p. 2024 - 2027 (2007/10/02)
3-Arylecgonine analogues were synthesized and characterized by 1H and 13C NMR, IR, and MS. The compounds were synthesized as racemates from cycloheptatriene-7-carboxylic acid or enantiomerically from (-)-cocaine. These analogues were tested for their ability to inhibit [3H]cocaine binding to bovine striatal tissue and to inhibit [3H]dopamine uptake into striatal synaptosomes. Methyl (1RS-2-exo-3-exo)-8-methyl-3-phenyl-8-azabicyclo[3.2.1]octane-2-carboxylate was the most potent analogue. IC50 values for inhibition of cocaine binding and dopamine uptake were 20 and 100 nM, respectively. The racemates and the 1R isomers were equally potent inhibitors of binding and uptake. Methyl (1RS-2-endo-3-exo)-3-(2,4-dinitrophenyl)-8-methyl-8- azabicyclo[3.2.1]octane-2-carboxylate was the least potent. IC50 for inhibition of both binding and uptake was 40 μM.
