43024-08-4Relevant articles and documents
A convenient, rapid, and general synthesis of α-oxo thiocyanates using clay supported ammonium thiocyanate
Meshram,Thakur, Pramod B.,Madhu Babu,Bangade, Vikas M.
experimental part, p. 1780 - 1785 (2012/05/04)
A very rapid, convenient, and general method for the synthesis of α-oxo thiocyanates has been described by using clay supported ammonium thiocyanate. The procedure avoids the use of additional catalyst, solvent, aqueous work-up and the yields are high. Moreover, the method is applicable for a variety of aryl, heteroaryl, alkyl α-halo carbonyls, β-keto tosylates, α-halo β-dicarbonyl, α-tosyl, β-dicarbonyl, alkyl halide, and alkyl tosylates.
Synthesis of novel N-thiazolo-1,3-oxathiol-2-imines from α-haloketones using potassium thiocyanate-silica gel
Aoyama, Tadashi,Arai, Izumi,Matsumoto, Takuo,Takido, Toshio,Kodomaric, Mitsuo
experimental part, p. 4113 - 4118 (2011/03/17)
Novel N-thiazolo-1,3-oxathiol-2-imines are synthesized by reaction of a-haloketones with potassium thiocyanate-silica gel. It is thought that the reaction occurs through conversion of the α-haloketone into the corresponding thiocyanate which then undergoes acid-catalyzed intramolecular cyclization to yield a cationic intermediate. Subsequent reaction of this intermediate with another molecule of the α-thiocyanatoketone and a second cyclization then gives the N-thiazolo-1,3-oxathiol-2-imine. Georg Thieme Verlag Stuttgart - New York.
