43042-79-1 Usage
Description
9ALPHA-11ALPHA, 15S-TRIHYDROXY-PROSTA-5Z, 13E-DIEN-1-OIC ACID, 1-GLYCERYL ESTER is a complex lipid molecule derived from the metabolism of arachidonyl glycerol (2-AG), a natural endocannabinoid ligand. It is formed through the interaction with cyclooxygenase-2 and specific prostaglandin H2 (PGH2) isomerases, resulting in the production of various PG glyceryl ester compounds. This molecule is characterized by its rapid equilibrium between the 2-glyceryl and 1-glyceryl ester moieties in aqueous media.
Uses
Used in Pharmaceutical Industry:
9ALPHA-11ALPHA, 15S-TRIHYDROXY-PROSTA-5Z, 13E-DIEN-1-OIC ACID, 1-GLYCERYL ESTER is used as an intermediate compound in the synthesis of various prostaglandin glyceryl ester derivatives. These derivatives have potential applications in the development of new drugs targeting various physiological and pathological processes.
Used in Research and Development:
In the field of research and development, 9ALPHA-11ALPHA, 15S-TRIHYDROXY-PROSTA-5Z, 13E-DIEN-1-OIC ACID, 1-GLYCERYL ESTER serves as a valuable tool for studying the biosynthesis, stability, and metabolism of prostaglandin glyceryl ester compounds. This knowledge can contribute to the understanding of their potential biological activities and therapeutic applications.
Used in Endocannabinoid System Studies:
As a derivative of the natural endocannabinoid ligand 2-AG, 9ALPHA-11ALPHA, 15S-TRIHYDROXY-PROSTA-5Z, 13E-DIEN-1-OIC ACID, 1-GLYCERYL ESTER can be used in the study of the endocannabinoid system, its role in various physiological processes, and its potential as a target for therapeutic intervention in various diseases and conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 43042-79-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 4,3,0,4 and 2 respectively; the second part has 2 digits, 7 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 43042-79:
(7*4)+(6*3)+(5*0)+(4*4)+(3*2)+(2*7)+(1*9)=91
91 % 10 = 1
So 43042-79-1 is a valid CAS Registry Number.
43042-79-1Relevant articles and documents
F2-Isoprostanes in HDL are bound to neutral lipids and phospholipids
Proudfoot, Julie M.,Barden, Anne E.,Croft, Kevin D.,Galano, Jean-Marie,Durand, Thierry,Bultel-Poncé, Valérie,Giera, Martin,Mori, Trevor A.
, p. 1374 - 1385 (2016)
Low HDL cholesterol (HDL-C) is a risk factor for coronary artery disease (CAD). However, interventions that raise HDL-C have failed to reduce cardiovascular events. We previously reported that HDL is the main carrier of plasma F2-isoprostanes (F2-IsoPs) that are markers of oxidative stress formed upon oxidation of arachidonic acid. F2-IsoPs are predominantly associated with phospholipids. However, there is evidence that F2-IsoPs in the liver of rats treated with carbon tetrachloride associate with the neutral lipids. To date it is not known whether F2-IsoPs are found in the neutral lipids in HDL in humans. Possible candidate neutral lipids include cholesteryl esters, triglycerides, diglycerides, and monoglycerides. This study aimed to identify the lipid classes within native and oxidized HDL that contain F2-IsoPs. We showed that F2-IsoPs in HDL are bound to neutral lipids as well as phospholipids. HDL-3 contained the highest concentration of F2-IsoPs in all lipid classes before and after in vitro oxidation. Using targeted LC/MS and high resolution MS, we were unable to provide conclusive evidence for the presence of the synthesized standards 15(R)-15-F2t-isoP cholesterol and 1-ent-15(RS)-15-F2t-isoprostanoyl-sn-glycerol in the neutral lipids of HDL. Our findings show that oxidized lipids such as F2-IsoPs are found in the core and surface of HDL. However, the exact molecular species remain to be definitively characterized. Future studies are required to determine whether the presence of F2-IsoPs in neutral lipids alters HDL function.
