43064-12-6

Basic information

• Product Name: 4-Phenyl-1,2,3,6-tetrahydropyridine hydrochloride
• Synonyms: 4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE HCL;4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE HYDROCHLORIDE;1,2,3,6-TETRAHYDRO-4-PHENYLPYRIDINE HYDROCHLORIDE;TIMTEC-BB SBB003589;4-Phenyl-1,2,3,6-tetrahydropyridine NCl;4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE HYDR OCHLORIDE, TECH.;4-Phenyl-1,2,3,6-tetrahydroxpyridine;1,2,3,6-Tetrahydropyridine-4-phenyl hydrochloride
• CAS NO: 43064-12-6
• Molecular Formula: C₁₁H₁₃N*ClH
• Molecular Weight: 195.69
• EINECS: 256-071-5
• Product Categories: Pyridines, Pyrimidines, Purines and Pteredines;Heterocyclic Compounds;C9 to C46;Heterocyclic Building Blocks;Pyridines;Building Blocks;C11;Chemical Synthesis;Heterocyclic Building Blocks
• Mol File: 43064-12-6.mol
• Article Data: 2

Chemical Properties

• Melting Point: 202-203.5 °C(lit.)
• Boiling Point: 267.9oC at 760 mmHg
• Flash Point: 119.9oC
• Appearance: light brown powder
• Vapor Pressure: 0.00792mmHg at 25°C
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility: Chloroform (Sparingly), Methanol (Slightly)
• Water Solubility: Soluble
• Stability: Hygroscopic
• CAS DataBase Reference: 4-Phenyl-1,2,3,6-tetrahydropyridine hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Phenyl-1,2,3,6-tetrahydropyridine hydrochloride(43064-12-6)
• EPA Substance Registry System: 4-Phenyl-1,2,3,6-tetrahydropyridine hydrochloride(43064-12-6)

Safety Data

• Hazard Codes: T,Xn
• Statements: 23/24/25-40-20/21/22
• Safety Statements: 28-36/37/39-38-45-28A-36
• RIDADR: UN 2811 6.1/PG 3
• WGK Germany: 3
• HazardClass: 6.1(b)
• PackingGroup: III
• Hazardous Substances Data: 43064-12-6(Hazardous Substances Data)

Usage

Description

4-Phenyl-1,2,3,6-tetrahydropyridine hydrochloride is a chemical compound that features a 4-phenyl-1,2,3,6-tetrahydropyridine fragment, which is a key structural element in benzamide derivatives. This fragment enhances the inhibitory potential of benzamide analogs against poly(ADP-ribose) polymerase-1 (PARP-1), a significant enzyme involved in various cellular processes. 4-Phenyl-1,2,3,6-tetrahydropyridine hydrochloride is characterized by its light brown powder form.

Uses

Used in Pharmaceutical Industry:
4-Phenyl-1,2,3,6-tetrahydropyridine hydrochloride is used as a pharmaceutical intermediate for the development of drugs targeting poly(ADP-ribose) polymerase-1 (PARP-1). Its presence in benzamide analogs improves their inhibitory potential against PARP-1, making it a valuable component in the creation of therapeutic agents for treating various diseases, including cancer.
Used in Research and Development:
In the field of scientific research, 4-Phenyl-1,2,3,6-tetrahydropyridine hydrochloride serves as a key compound for studying the interactions between PARP-1 and benzamide derivatives. This research can lead to a better understanding of the enzyme's role in disease processes and the development of more effective treatments.
Used in Drug Synthesis:
4-Phenyl-1,2,3,6-tetrahydropyridine hydrochloride is utilized in the synthesis of novel drugs that aim to modulate the activity of PARP-1. Its incorporation into drug molecules can enhance their efficacy and selectivity, potentially leading to improved therapeutic outcomes for patients.
Overall, 4-Phenyl-1,2,3,6-tetrahydropyridine hydrochloride plays a crucial role in the pharmaceutical and research industries, contributing to the advancement of treatments for various diseases and the deepening of our understanding of PARP-1's biological functions.

Upstream product

• 108-86-1 bromobenzene 
• 3612-20-2 1-phenylmethyl-4-piperidone 
• 38025-45-5 1-benzyl-4-phenyl-1,2,3,6-tetrahydro-pyridine 
• 63843-83-4 1-benzyl-4-hydroxy-4-phenylpiperidine 
• 79099-07-3 N-tert-butyloxycarbonylpiperidin-4-one 

Downstream Products

• 21820-81-5 5-[2-(4-phenyl-3,6-dihydro-2H-pyridin-1-yl)-ethyl]-oxazolidin-2-one 
• 21820-82-6 3-methyl-5-[2-(4-phenyl-3,6-dihydro-2H-pyridin-1-yl)-ethyl]-oxazolidin-2-one 
• 143682-24-0 2-(1H-Indol-3-yl)-1-(4-phenyl-3,6-dihydro-2H-pyridin-1-yl)-ethanone 
• 143682-25-1 3-(1H-Indol-3-yl)-1-(4-phenyl-3,6-dihydro-2H-pyridin-1-yl)-propan-1-one 
• 73966-54-8 1-<4-(3-indolyl)butanoyl>-1,2,3,6-tetrahydro-4-phenylpyridine 
• 143682-29-5 4-(2-Methyl-1H-indol-3-yl)-1-(4-phenyl-3,6-dihydro-2H-pyridin-1-yl)-butan-1-one 
• 143682-26-2 5-(1H-Indol-3-yl)-1-(4-phenyl-3,6-dihydro-2H-pyridin-1-yl)-pentan-1-one 
• 143682-30-8 4-(5-Fluoro-1H-indol-3-yl)-1-(4-phenyl-3,6-dihydro-2H-pyridin-1-yl)-butan-1-one 
• 143682-31-9 4-(5-Chloro-1H-indol-3-yl)-1-(4-phenyl-3,6-dihydro-2H-pyridin-1-yl)-butan-1-one 
• 143682-28-4 4-(1-Methyl-1H-indol-3-yl)-1-(4-phenyl-3,6-dihydro-2H-pyridin-1-yl)-butan-1-one 
• 143682-27-3 6-(1H-Indol-3-yl)-1-(4-phenyl-3,6-dihydro-2H-pyridin-1-yl)-hexan-1-one 
• 143682-33-1 4-(6-Methoxy-1H-indol-3-yl)-1-(4-phenyl-3,6-dihydro-2H-pyridin-1-yl)-butan-1-one 
• 165590-67-0 1-<(1,4-dioxaspiro<4.5>decan-6-yl)carbonyl>-1,2,3,6-tetrahydro-4-phenylpyridine 
• 165590-70-5 1,2,3,6-tetrahydro-1-<(3-oxocyclohexyl)carbonyl>-4-phenylpyridine 

Relevant articles and documents

POLY-ADP RIBOSE POLYMERASE (PARP) INHIBITORS

The present invention is related to a pharmaceutical composition comprising a pharmaceutically acceptable carrier or diluent and a compound represented by the following structural formula: The present invention is also related a method of treating a subject with a disease which can be ameliorated by inhibition of poly(ADP-ribose)polymerase (PARP). The definitions of the variables are provided herein.