43091-89-0Relevant articles and documents
Triazoloquinazolines as a novel class of phosphodiesterase 10A (PDE10A) inhibitors
Kehler, Jan,Ritzen, Andreas,Langgard, Morten,Petersen, Sebastian Leth,Farah, Mohamed M.,Bundgaard, Christoffer,Christoffersen, Claus Tornby,Nielsen, Jacob,Kilburn, John Paul
, p. 3738 - 3742 (2011)
Novel triazoloquinazolines have been found as phosphodiesterase 10A (PDE10A) inhibitors. Structure-activity studies improved the initial micromolar potency which was found in the lead compound by a 100-fold identifying 5-(1H-benzoimidazol-2-ylmethylsulfan
New syntheses of aryl isothiocyanates
Besson, Thierry,Guillard, Jerome,Rees, Charles W.,Thiery, Valerie
, p. 889 - 892 (2007/10/03)
Primary aromatic amines are readily converted into arylimino-1,2,3-dithiazoles 2 and the derived cyanothioformanilides 6, both of which are rapidly cleaved by ethylmagnesium bromide in hot THF to give the corresponding isothiocyanates. The transformation 2→6→ArNCS can be performed as a 'one-pot' operation. The imines 2 are also converted, more slowly, into the isothiocyanates by sodium hydride in hot THF, via the cyanothioformanilides 6. Conversion of the anilides 6 into isothiocyanates is much faster under microwave irradiation in 2,6-lutidine. Mechanisms are proposed for these reactions.
New practical synthesis of prazosin
Honkanen,Pippuri,Kairisalo,et al.
, p. 797 - 798 (2007/10/02)
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