43107-11-5

Basic information

• Product Name: 2-Butenoic acid, 3-amino-, phenylmethyl ester
• CAS NO: 43107-11-5
• Molecular Formula: C11H13NO2
• Molecular Weight: 191.23
• Mol File: 43107-11-5.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 2-Butenoic acid, 3-amino-, phenylmethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Butenoic acid, 3-amino-, phenylmethyl ester(43107-11-5)
• EPA Substance Registry System: 2-Butenoic acid, 3-amino-, phenylmethyl ester(43107-11-5)

Safety Data

• Hazardous Substances Data: 43107-11-5(Hazardous Substances Data)

Upstream product

• 5396-89-4 benzyl acetoacetate 

Downstream Products

• 118170-49-3 benzyl (Z)-3-butanamido-2-butenoate 
• 505092-89-7 benzyl (Z)-β-acetylamino butenoate 
• 505092-90-0 benzyl (E)-β-acetylamino butenoate 
• 122549-29-5 4-(4-Fluorophenyl)-1,4-dihydro-2-methyl-6-(trifluoromethyl)-3,5-pyridinedicarboxylic acid, 5-ethyl 3-phenylmethyl ester 
• 142161-44-2 4-(2-Chloro-phenyl)-2-methyl-6-[4-(2-methyl-imidazo[4,5-c]pyridin-1-yl)-phenyl]-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-benzyl ester 5-ethyl ester 
• 915296-80-9 3-benzyl 5-ethyl 6-(chloromethyl)-4-(2,4-dichlorophenyl)-2-methyl-1,4-dihydropyridine-3,5-dicarboxylate 
• 915296-82-1 benzyl 4-(2,4-dichlorophenyl)-6-(4-methoxyphenyl)-2-methyl-5-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyridine-3-carboxylate 
• 915297-04-0 benzyl 6-(2-tert-butoxy-2-oxoethyl)-4-(2,4-dichlorophenyl)-2-methyl-5-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyridine-3-carboxylate 
• 915296-81-0 3-benzyl 5-ethyl 6-(chloromethyl)-4-(2,4-dichlorophenyl)-2-methylpyridine-3,5-dicarboxylate 

Relevant articles and documents

Synthesis method of amlodipine besylate degradant impurities

The invention provides a preparation method of amlodipine besylate degradant impurities. The method comprises the following steps: a) preparation of a compound 1: generating corresponding imine, namely, the compound 1 by using an acetylacetic ester compou

Optimization of activity, selectivity, and liability profiles in 5-oxopyrrolopyridine DPP4 inhibitors leading to clinical candidate (Sa)-2-(3-(aminomethyl)-4-(2,4-dichlorophenyl)-2-methyl-5-oxo-5H-pyrrolo[3,4-b] pyridin-6(7H)-yl)-N, N-dimethylacetamide (BMS-767778)

Optimization of a 5-oxopyrrolopyridine series based upon structure-activity relationships (SARs) developed from our previous efforts on a number of related bicyclic series yielded compound 2s (BMS-767778) with an overall activity, selectivity, efficacy, PK, and developability profile suitable for progression into the clinic. SAR in the series and characterization of 2s are described.

Direct β-acyloxylation of enamines via PhIO-mediated intermolecular oxidative C-O bond formation and its application to the synthesis of oxazoles

A direct β-acyloxylation of enamine compounds has been achieved by using iodosobenzene (PhIO) as an oxidant to realize the intermolecular oxidative C(sp2)-O bond formation between enamines and various carboxylic acids, including N-protected amino acids. The transformation tolerates a wide range of functional groups and furnishes a variety of β-acyloxy enamines that can be conveniently converted to oxazole compounds via cyclodehydration.