43181-78-8

Basic information

• Product Name: 2-CHLORO-1-(PHENYLMETHYL)-BENZIMIDAZOLE
• Synonyms: 2-CHLORO-1-(PHENYLMETHYL)-BENZIMIDAZOLE;1-Benzyl-2-chloro-1H-benzoiMidazole
• CAS NO: 43181-78-8
• Molecular Formula: C₁₄H₁₁ClN₂
• Molecular Weight: 242.7
• Mol File: 43181-78-8.mol
• Article Data: 16

Chemical Properties

• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 2-CHLORO-1-(PHENYLMETHYL)-BENZIMIDAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLORO-1-(PHENYLMETHYL)-BENZIMIDAZOLE(43181-78-8)
• EPA Substance Registry System: 2-CHLORO-1-(PHENYLMETHYL)-BENZIMIDAZOLE(43181-78-8)

Safety Data

• Hazardous Substances Data: 43181-78-8(Hazardous Substances Data)

Usage

General Description

2-Chloro-1-(phenylmethyl)-benzimidazole is a chemical compound with the molecular formula C14H11ClN2. It is a benzimidazole derivative with a chlorine atom and a phenylmethyl group attached to the benzimidazole ring. 2-CHLORO-1-(PHENYLMETHYL)-BENZIMIDAZOLE has potential application in pharmaceutical research, particularly for its potential as an anti-cancer agent. It may also have uses in other areas such as organic synthesis and chemical research. However, further research and testing are necessary to fully understand its potential uses and properties.

Upstream product

• 4857-06-1 2-chloro-1H-benzoimidazole 
• 100-44-7 benzyl chloride 
• 100-39-0 benzyl bromide 
• 615-16-7 1H-benzimidazol-2-ol 
• 5822-13-9 N-benzyl-1,2-phenylenediamine 
• 28643-53-0 1,3-dihydro-1-(phenylmethyl)-2H-benzimidazol-2-one 
• 88-74-4 2-nitro-aniline 
• 5729-06-6 N-benzyl-2-nitroaniline 

Downstream Products

• 57897-96-8 1-Benzyl-2-(4-methyl-piperazin-1-yl)-1H-benzoimidazole 
• 143257-98-1 lerisetron 
• 250342-76-8 1-benzyl-2-(4'-methoxy-biphenyl-4-yl)-1H-benzoimidazole 
• 51314-51-3 N-butyl-1H-benzo[d]imidazol-2-amine 
• 75971-14-1 N-(1-methyl-4-piperidinyl)-1-(phenylmethyl)-1H-benzimidazol-2-amine 
• 14180-45-1 (1-benzyl-2-benzimidazolyl)hydrazine 
• 1331868-32-6 (S)-2-((1-benzyl-1H-benzo[d]imidazol-2-yl)oxy)-N-(2-chloro-4-methylphenyl)propanamide 
• 1393082-69-3 C₃₇H₄₀N₂O₃S 
• 882236-02-4 C₂₄H₂₁N₅ 
• 920939-74-8 C₃₂H₂₇N₅O 
• 554424-57-6 C₃₁H₂₄ClN₅ 
• 31493-51-3 N-benzyl-2-mercaptobenzimidazole 
• 52986-15-9 1-benzyl-2-deuterio-1H-benzo[d]imidazole 
• 111678-96-7 (1-Benzyl-1H-benzoimidazol-2-yl)-(2-chloro-ethyl)-amine 

Relevant articles and documents

Intermolecular [2 + 2] Photocycloaddition of α,β-Unsaturated Sulfones: Catalyst-Free Reaction and Catalytic Variants

2-Aryl-1-sulfonyl-substituted cyclobutanes were prepared in an intermolecular [2 + 2] photocycloaddition from various α,β-unsaturated sulfones and olefins upon irradiation at λ = 300 nm (26 examples, 60-99% yield). Lewis acids catalyzed the [2 + 2] photocycloaddition of 2-benzimidazolyl styryl sulfones. At short wavelengths, the latter substrates underwent C-S bond cleavage but AlBr3 (5 mol %) allowed for an intermolecular reaction with 2,3-dimethyl-2-butene at longer wavelengths. A chiral-at-metal Lewis acid (2 mol %) facilitated an enantioselective reaction (up to 77% ee).

Benzoxaborolane compounds and preparation method thereof

The invention relates to benzoxaborolane compounds and pharmaceutically acceptable salts or solvates thereof. The structure of the compounds is shown in the description, wherein B is boron; X is selected from oxygen, sulfur, nitrogen and hydrogen; R1 is s

Synthesis and biological evaluation of 2,3-dihydroimidazo[1,2-a] benzimidazole derivatives against Leishmania donovani and Trypanosoma cruzi

A high-throughput (HTS) and high-content screening (HCS) campaign of a commercial library identified 2,3-dihydroimidazo[1,2-a]benzimidazole analogues as a novel class of anti-parasitic agents. A series of synthetic derivatives were evaluated for their in vitro anti-leishmanial and anti-trypanosomal activities against Leishmania donovani and Trypanosoma cruzi, which have been known as the causative parasites for visceral leishmaniasis and Chagas disease, respectively. In the case of Leishmania, the compounds were tested in both intracellular amastigote and extracellular promastigote assays. Compounds 4 and 24 showed promising anti-leishmanial activity against intracellular L. donovani (3.05 and 5.29 μM, respectively) and anti-trypanosomal activity against T. cruzi (1.10 and 2.10 μM, respectively) without serious cytotoxicity toward THP-1 and U2OS cell lines.