43189-09-9

Basic information

• Product Name: 2-(p-Hydroxyphenyl)glycine Ethyl Ester
• Synonyms: 2-(p-Hydroxyphenyl)glycine Ethyl Ester
• CAS NO: 43189-09-9
• Molecular Weight: 195.218
• Mol File: 43189-09-9.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 2-(p-Hydroxyphenyl)glycine Ethyl Ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(p-Hydroxyphenyl)glycine Ethyl Ester(43189-09-9)
• EPA Substance Registry System: 2-(p-Hydroxyphenyl)glycine Ethyl Ester(43189-09-9)

Safety Data

• Hazardous Substances Data: 43189-09-9(Hazardous Substances Data)

Usage

General Description

2-(p-Hydroxyphenyl)glycine Ethyl Ester, also known as Ethyl 2-(p-hydroxyphenyl)glycinate, is a chemical compound used in the production of pharmaceuticals, fragrances, and organic synthesis. It is an ester derivative of p-hydroxyphenylglycine, which is an important intermediate in the synthesis of pharmaceuticals such as gabapentin. 2-(p-Hydroxyphenyl)glycine Ethyl Ester is often used as a building block in the synthesis of various drugs and bioactive molecules. It is also utilized in the preparation of flavors and fragrances due to its aromatic properties. Furthermore, 2-(p-Hydroxyphenyl)glycine Ethyl Ester has been found to exhibit antioxidant activity, making it potentially useful in the production of antioxidant supplements and food additives.

Upstream product

• 64-17-5 ethanol 
• 6324-01-2 p-hydroxyphenylglycine 
• 70080-54-5 4-hydroxy-alpha-oxobenzeneacetic acid ethyl ester 
• 108-95-2 phenol 

Downstream Products

• 70875-51-3 2-glycine Ethyl Ester Hydrotosylate 
• 77629-98-2 Diethyl 3-Azido-α--2-oxo-1-azetidinemalonate 
• 70875-48-8 Ethyl α--2-oxo-1-azetidineacetate 
• 71725-07-0 Diethyl α--2-oxo-1-azetidinemalonate 
• 70875-42-2 2--N-(3-bromopropionyl)glycine Ethyl Ester 
• 1473359-00-0 ethyl 2-[(5-[(2-amino-6-oxo-6,9-dihydro-1H-9-purinyl)methoxy]-2-oxo-1,3,2λ⁵-dioxaphosphinan-2-ylmethyl)amino] 2-(4-hydroxyphenyl)acetate 

Relevant articles and documents

Preparation method of amino-acid ester

The invention relates to a preparation method of amino-acid ester, and belongs to the field of synthesis of organic compounds. The preparation method of the amino-acid ester comprises the following steps: taking sulfur trioxide as a catalyst and a water-binding agent, catalyzing amino acid and alcohol to react so as to prepare sulfate of the amino-acid ester, then concentrating a reaction system to remove a reaction solvent and then adding water for dissolving, and neutralizing ammonia water to prepare the amino-acid ester. According to the technical scheme, the provided preparation method ofthe amino-acid ester has the advantages of mild reaction process, high yield, good purity, simplicity in operation and low cost. Concentrated condensate water of central mother liquor of the preparation method of the amino-acid ester can be directly subjected to biochemical treatment, solid by-products are high-purity ammonium sulfate, and can serve as chemical fertilizers, a reaction process is green and pollution-free, and thus, environmental protection is facilitated.

Inhibitors of lipoprotein(a) assembly

Compounds of the general structure A and B were investigated for their activity as lipoprotein(a), [Lp(a)], assembly (coupling) inhibitors. SAR around the amino acid derivatives (structure A) gave compound 14-6 as a potent coupling inhibitor. Oral dosing

A new asymmetric transformation of alpha-amino-acid esters with (+)-tartaric acid.

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