432545-63-6 Usage
Description
METHOTREXATE-D3 is an isotope-labeled analog of Methotrexate Triglutamate, a metabolite of Methotrexate, which is a folic acid antagonist, antineoplastic, and antirheumatic. It is a yellow solid and is used in various applications due to its unique properties.
Uses
Used in Pharmaceutical Industry:
METHOTREXATE-D3 is used as an antineoplastic agent for the treatment of various types of cancer. It works by inhibiting the activity of dihydrofolate reductase, an enzyme essential for DNA synthesis and cell replication, thus preventing the growth and spread of cancer cells.
METHOTREXATE-D3 is also used as an antirheumatic agent for the treatment of autoimmune diseases such as rheumatoid arthritis. It helps to reduce inflammation and pain associated with the condition by suppressing the immune system.
Additionally, METHOTREXATE-D3 can be used in research applications, particularly in the study of folic acid metabolism and the development of new drugs targeting this pathway. Its isotope-labeled nature allows for easier tracking and analysis in experimental settings.
Check Digit Verification of cas no
The CAS Registry Mumber 432545-63-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,3,2,5,4 and 5 respectively; the second part has 2 digits, 6 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 432545-63:
(8*4)+(7*3)+(6*2)+(5*5)+(4*4)+(3*5)+(2*6)+(1*3)=136
136 % 10 = 6
So 432545-63-6 is a valid CAS Registry Number.
432545-63-6Relevant articles and documents
Synthesis of [C2H3]methotrexate and [C2H3]7-hydroxymethotrexate
Elmore, Charles S.,Dean, Dennis C.,Zhang, Yong,Gibson, Carter,Jenkins, Herb,Jones, Allen N.,Melillo, David G.
, p. 29 - 36 (2007/10/03)
Stable label analogues of methotrexate (MTX) and 7-hydroxymethotrexate (7-OH-MTX) were required for use as internal standards for LC/MS quantitation. A minimum incorporation of stable isotopes to produce a mass increase of 3 in the non-glutamate derived p
