433230-25-2

Basic information

• Product Name: (3-{(4R,5S)-2-Acetoxy-4-hydroxy-5-[(E)-(S)-3-hydroxy-4-(4-hydroxy-phenyl)-but-1-enyl]-cyclopent-1-enylsulfanyl}-propylsulfanyl)-acetic acid methyl ester
• CAS NO: 433230-25-2
• Molecular Weight: 482.619
• Mol File: 433230-25-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (3-{(4R,5S)-2-Acetoxy-4-hydroxy-5-[(E)-(S)-3-hydroxy-4-(4-hydroxy-phenyl)-but-1-enyl]-cyclopent-1-enylsulfanyl}-propylsulfanyl)-acetic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (3-{(4R,5S)-2-Acetoxy-4-hydroxy-5-[(E)-(S)-3-hydroxy-4-(4-hydroxy-phenyl)-but-1-enyl]-cyclopent-1-enylsulfanyl}-propylsulfanyl)-acetic acid methyl ester(433230-25-2)
• EPA Substance Registry System: (3-{(4R,5S)-2-Acetoxy-4-hydroxy-5-[(E)-(S)-3-hydroxy-4-(4-hydroxy-phenyl)-but-1-enyl]-cyclopent-1-enylsulfanyl}-propylsulfanyl)-acetic acid methyl ester(433230-25-2)

Safety Data

• Hazardous Substances Data: 433230-25-2(Hazardous Substances Data)

Upstream product

• 433228-93-4 (3S,4R)-1-acetoxy-4-(tert-butyldimethylsiloxy)-3-(trans-2-iodovinyl)-2-(6-methoxycarbonyl-1,5-dithiahexyl)-1-cyclopentene 
• 7339-87-9 4-hydroxyphenylacetaldehyde 

Relevant articles and documents

Design and synthesis of a selective EP4-receptor agonist. Part 2: 3,7-dithiaPGE1 derivatives with high selectivity

To identify new highly selective EP4-agonists, further modification of the 16-phenyl moiety of 1 was continued. 16-(3-Methoxymethyl)phenyl derivatives 13-6q and 16-(3-ethoxymethyl)phenyl derivatives 13-7e showed more selectivity and potent agonist activity than 1. 16-(3-Methyl-4-hydroxy)phenyl derivative 18-14e demonstrated excellent subtype selectivity, while both its receptor affinity and agonist activity were less potent than those of 13-6q. Structure activity relationships (SARs) are also d scussed. Copyright