4369-12-4

Basic information

• Product Name: 4-Piperidinone, 3,5-bis[(4-methoxyphenyl)methylene]-1-methyl-
• Synonyms: (E)-1-methyl-3,5-bis(4-methoxybenzylidene)-4-piperidone;3,5-bis-(4-methoxy-benzylidene)-1-methyl-piperidin-4-one;3,5-bis(4-methoxybenzylidene)-1-methyl-4-piperidone;3,5-bis(p-methoxybenzylidene)-1-methyl-4-piperidone;3,5-Bis-(4-methoxy-benzyliden)-1-methyl-4-piperidon;3,5-Bis-(4-methoxy-benzyliden)-1-methyl-piperidin-4-on
• CAS NO: 4369-12-4
• Molecular Formula: C22H23NO3
• Molecular Weight: 349.43
• Mol File: 4369-12-4.mol
• Article Data: 21

Chemical Properties

• CAS DataBase Reference: 4-Piperidinone, 3,5-bis[(4-methoxyphenyl)methylene]-1-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Piperidinone, 3,5-bis[(4-methoxyphenyl)methylene]-1-methyl-(4369-12-4)
• EPA Substance Registry System: 4-Piperidinone, 3,5-bis[(4-methoxyphenyl)methylene]-1-methyl-(4369-12-4)

Safety Data

• Hazardous Substances Data: 4369-12-4(Hazardous Substances Data)

Upstream product

• 1445-73-4 1-Methyl-4-piperidone 
• 123-11-5 4-methoxy-benzaldehyde 

Downstream Products

• 1174000-24-8 2-amino-5,6,7,8-tetrahydro-8-(4-methoxybenzylidene)-4-(4-methoxyphenyl)-6-methyl-1,6-naphthyridine-3-carbonitrile 
• 1623098-50-9 (E)-8-(4-methoxybenzylidene)-5,6,7,8-tetrahydro-4-(4-methoxyphenyl)-6-methyl-2-phenylpyrido[4,3-d]pyrimidine 

Relevant articles and documents

Design, synthesis of novel pyrazolopyridine derivatives and CREBBP bromodomain inhibitors docking and molecular dynamics

A sequence of novel compounds pyrazolopyridine have been prepared by a general synthetic method. Due to high efficiency and selectivity, anticancer agents consisting of combined molecules have gained great interests. The IC50 values have been determined against cell line U937, the results obtained indicate the potential effects against cancer cell line. The cell potency of cell line is best for compounds 4a IC50 = 62.5 μM, 5b IC50 = 62.5 μM,4b IC50 = 31.2 μM, 4e IC50 = 31.2 μM), selectivity and in vivo. Further, the molecular docking studies indicate that substituted pyrazolo[4,3-c]pyridine derivatives show good anticancer activity in the medicinal field. The ease of synthesis and the significant biological activities make these compounds potential new frameworks for progress of cancer therapeutics. Compound 4f shows anticancer effect in cancer cell lines and in vivo that corresponds with antitumor activity in an AML cancer type. For the molecular docking with the ligands, the RMSD value has been calculated, the protein with the least RMSD is found to be 5KTU screening with 20 small molecules.

Disubstituted aryl compound and application thereof

The invention relates to bis-substituted aryl compounds and application thereof. The structure of the bis-substituted aryl compounds is disclosed as Formula I, II or III. The experimental verification detects that the bis-substituted aryl compounds can be

For anti-tumor N - methyl - 3, 5 - aryl methylene - 4 - piperidone and its quaternary ammonium salt derivatives

The invention relates to antitumor drugs and particularly relates to an anti-tumor N-methyl-3,5-diarylmethylene-4-piperidone and quaternary ammonium derivatives thereof. The preparation method comprises the following steps of carrying out Claisen-Schmidt