437608-70-3

Basic information

• Product Name: 4-((4-amino-5-mercapto-4H-1,2,4-triazol-3-yl)methyl)phenol
• Synonyms: 4-((4-amino-5-mercapto-4H-1,2,4-triazol-3-yl)methyl)phenol
• CAS NO: 437608-70-3
• Molecular Weight: 222.271
• Mol File: 437608-70-3.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 4-((4-amino-5-mercapto-4H-1,2,4-triazol-3-yl)methyl)phenol(CAS DataBase Reference)
• NIST Chemistry Reference: 4-((4-amino-5-mercapto-4H-1,2,4-triazol-3-yl)methyl)phenol(437608-70-3)
• EPA Substance Registry System: 4-((4-amino-5-mercapto-4H-1,2,4-triazol-3-yl)methyl)phenol(437608-70-3)

Safety Data

• Hazardous Substances Data: 437608-70-3(Hazardous Substances Data)

Upstream product

• 156-38-7 4-hydroxyphenylacetate 
• 2231-57-4 Thiocarbohydrazide 
• 75-15-0 carbon disulfide 
• 20277-02-5 2-(4-hydroxyphenyl)acetatic acid hydrazide 

Relevant articles and documents

Discovery of [1,2,4]triazolo[3,4-b][1,3,4]thiadiazole derivatives as novel, potent and selective c-Met kinase inhibitors: Synthesis, SAR study, and biological activity

A series of [1,2,4]triazolo[3,4-b][1,3,4]thiadiazole derivatives were designed, synthesized and evaluated for their biological activity. Most of these compounds showed potent activities against c-Met kinase and cell growth inhibition. The most promising compound, 7d, has the IC50 values of 2.02 and 88 nM to inhibit c-Met kinase activity and cell growth in the MKN45 cell line, respectively. In addition, 7d is highly selective to c-Met and exhibits over 2500-fold selective inhibition to 16 tyrosine kinases evaluated.

Preparation method and applications of triazolo-thiadiazole c-Met kinase inhibitor

The invention relates to the field of pharmaceutical chemistry, and specifically relates to [1,2,4]triazolo[3,4-b][1,3,4]thiadiazole derivatives, a preparation method thereof, a pharmaceutical composition comprising the same, and medical applications thereof, in particular, an application as a c-Met kinase inhibitor.

Synthesis, antibacterial and antifungal activity of 4-substituted-5-aryl-1, 2,4-triazoles

A few 4-allyl/amino-5-aryl-1,2,4-triazoles were synthesized and tested for antibacterial and antifungal effects against Escherichia coli, Bacillus subtilis, Salmonella enteritidis, Staphylococcus aureus, Aspergillus niger and Candida albicans. 4-Allyl-5-aryl-1,2,4-triazoles were obtained by the oxidative cyclization of the appropriate 1-substituted-4-allylthiosemicarbazides and 4-amino-5-aryl-1,2,4-triazoles were obtained by cyclization of the potassium salts of appropriately substituted dithiocarbazinic acids with hydrazine hydrate. The new synthesized compounds were characterized using IR, 1H- NMR, 13C-NMR and UV spectral data together with elemental analysis.