438475-37-7Relevant articles and documents
Water-soluble derivatives of octanuclear iron-oxido-pyrazolato complexes - An experimental and computational study
Das, Soma,Chakraborty, Indranil,Skachkov, Dmitry,Ahmadi, Majid,Ishikawa, Yasuyuki,Baran, Peter,Raptis, Raphael G.
, p. 3704 - 3711 (2012)
Two water-soluble iron-pyrazolato complexes (compounds 3 and 4), [Fe 8], have been prepared by introducing twelve hydroxyalkyl groups to the periphery of the approximately spherical octanuclear molecule. They are contrasted with their two organosoluble chloroalkyl analogues (compounds 1 and 2). All four complexes were characterized in solution by 1H NMR and electrospray ionization mass spectrometry. The one-electron-reduction product of water-soluble 3, [Fe8]-, was structurally characterized by single-crystal X-ray diffraction analysis. In aqueous media, the four terminal Fe-Cl bonds of [Fe8] are partially hydrolyzed, and the resulting chlorido-aqua-hydroxido species form supramolecular nanoscale aggregates, as determined by dynamic light scattering and electron microscopy. Preliminary computational studies with DFT methods were employed to model the H-bonding interactions controlling the competing solvation and aggregation processes. Twelve hydroxyalkyl pendant groups render an octanuclear iron-oxido-pyrazolato complex soluble in water, where partial hydrolysis and extended intermolecular H-bonding interactions result in supramolecular assemblies. Copyright
HETEROARYL-CARBOXAMIDES AS HISTONE DEMETHYLASE INHIBITORS
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Page/Page column 81, (2019/01/04)
The invention relates to heteroaryl-carboxamides as described herein, useful as histone demethyiase inhibitors. The invention also relates to pharmaceutical compositions comprising these compounds and to their use in therapy, including e.g., in the treatment of cancer.
